Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Feb 28;48(1):59-62.
doi: 10.5125/jkaoms.2022.48.1.59.

Intraductal papilloma of the sublingual gland imitating a ranula

Affiliations
Case Reports

Intraductal papilloma of the sublingual gland imitating a ranula

Dimitris Tatsis et al. J Korean Assoc Oral Maxillofac Surg. .

Abstract

Ductal papillomas are rare benign lesions of the salivary glands with two distinctive types, intraductal and inverted. The rarest anatomical location where intraductal papillomas occur is the major salivary glands. In the present study, we report an intraductal papilloma of the left sublingual gland with the relevant clinical, imaging, and histopathological findings and postoperative follow-up. To our knowledge, this is the fourth case of an intraductal papilloma of a sublingual gland to be reported in the international literature. We present this rare case because of its clinical and radiological imitation of a ranula.

Keywords: Intraductal papilloma; Sublingual gland.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Preoperative photograph of the lesion.
Fig. 2
Fig. 2
Preoperative magnetic resonance imaging, T2-weighted image. A. Axial plane. B. Coronal plane. C. Sagittal plane.
Fig. 3
Fig. 3
Postoperative magnetic resonance imaging. A. Axial plane. B. Coronal plane.
Fig. 4
Fig. 4
Intraoperative photograph during the resection of the lesion.
Fig. 5
Fig. 5
Histopathological findings. A. Panoramic view of the intraductal papilloma arranged in tubular and papillary formations with thin fibrovascular cores (H&E staining, ×40). B. The neoplastic cells are of medium size, cylindrical, with eosinophilic cytoplasm and ovoid nuclei, and without atypia or mitotic activity (H&E staining, ×200). C. There was no infiltration of the neoplastic cells in the ductal wall (H&E staining, ×200).

References

    1. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. 4th ed. IARC (International Agency for Research on Cancer); Lyon: 2017.
    1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. IARC; Lyon: 2008. pp. 202–8.
    1. Choi G, Choi CS, Choi JS, Choi JO. Intraductal papilloma of the parotid gland in a child. Otolaryngol Head Neck Surg. 2001;125:280. doi: 10.1067/mhn.2001.115666. https://doi.org/10.1067/mhn.2001.115666. - DOI - PubMed
    1. Brannon RB, Sciubba JJ, Giulani M. Ductal papillomas of salivary gland origin: a report of 19 cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:68–77. doi: 10.1067/moe.2001.115978. https://doi.org/10.1067/moe.2001.115978. - DOI - PubMed
    1. Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, et al. Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:e34–7. doi: 10.1016/j.tripleo.2009.01.019. Erratum in: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:475. https://doi.org/10.1016/j.tripleo.2009.01.019 . - DOI - PubMed

Publication types