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. 2022 Feb 10:16:814684.
doi: 10.3389/fnins.2022.814684. eCollection 2022.

Traumatic Brain Injury Is Associated With Both Hemorrhagic Stroke and Ischemic Stroke: A Systematic Review and Meta-Analysis

Donghao Qu  1 , Wenchen Li  1 , Shuyan Zhang  1 , Ri Li  2 , Haifeng Wang  1 , Bo Chen  1
Affiliations

Traumatic Brain Injury Is Associated With Both Hemorrhagic Stroke and Ischemic Stroke: A Systematic Review and Meta-Analysis

Donghao Qu et al. Front Neurosci. .

Abstract

Background: Traumatic brain injury (TBI) is considered a risk factor for the development of stroke (Hemorrhagic Stroke and Ischemic Stroke). We performed this systemic review and meta-analysis to determine the association of prior TBI with the subsequent diagnosis of stroke.

Methods: We systematically searched PubMed, EMBASE, and the Cochrane Library for cohort studies involving TBI patients who subsequently developed stroke. Study selection, data extraction, and quality assessment were performed by two separate researchers. Data were analyzed with random-effects models, and a secondary analysis stratified by the type of stroke was performed.

Results: Of the 741 identified studies, 6 studies were eligible for inclusion, with more than 2,200,000 participants. TBI predicted the occurrence of stroke in the random-effect model, with a relative risk of 2.14 (95% CI 1.97-2.32, P < 0.001). Furthermore, in the analysis of each type of stroke, TBI was associated with the incidence of ischemic stroke (RR 1.351 95% CI 1.212-1.506, P < 0.001), and TBI was associated with an even greater increase in the incidence of hemorrhagic stroke (RR 6.118 95% CI 5.265-7.108, P < 0.001).

Conclusion: Our meta-analysis showed that TBI was associated with a more than two-fold increase in the risk of stroke. However, owing to the high degree of heterogeneity, decisions should be made on a patient-by-patient basis. The occurrence of TBI is associated with the development of both hemorrhagic and ischemic stroke, and the risk of hemorrhagic stroke is much higher than that of ischemic stroke in TBI patients.

Keywords: hemorrhagic stroke; ischemic stroke; meta-analysis; risk factor; traumatic brain injury.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the literature search.
Figure 2
Figure 2
Forest plots of the association between traumatic brain injury and future stroke in all included studies. The meta-analysis was performed using a random-effects model. The overall analysis is shown. Diamonds represent the pooled estimates, and the horizontal lines represent the 95% confidence intervals. RR, relative risk; CI, confidence interval.
Figure 3
Figure 3
Forest plots of the association between traumatic brain injury and future stroke in all included studies. The meta-analysis was performed using a random-effects model. The subgroup analysis is shown. Diamonds represent the pooled estimates, and the horizontal lines represent the 95% confidence intervals. RR, relative risk; CI, confidence interval.
See this image and copyright information in PMC

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