Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

Claudia Duran-Aniotz^{1

2}, Ines Moreno-Gonzalez^{3

4

5

6}, Danilo B Medinas^{7

8

9}, Rodrigo Morales^{5

6}

Affiliations

¹ Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
² Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibanez, Santiago, Chile.
³ Departamento Biologia Celular, Genetica y Fisiologia, Facultad de Ciencias, Instituto de Investigacion Biomedica de Malaga-IBIMA, Universidad de Malaga, Málaga, Spain.
⁴ Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
⁵ Centro Integrativo de Biología y Química Aplicada, Universidad Bernardo O'Higgins, Santiago, Chile.
⁶ Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, United States.
⁷ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.
⁸ Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
⁹ Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

PMID: 35221985
PMCID: PMC8864239
DOI: 10.3389/fnagi.2021.830779

Editorial

Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

Claudia Duran-Aniotz et al. Front Aging Neurosci. 2022.

. 2022 Feb 9:13:830779.

doi: 10.3389/fnagi.2021.830779. eCollection 2021.

Authors

Claudia Duran-Aniotz^{1

2}, Ines Moreno-Gonzalez^{3

4

5

6}, Danilo B Medinas^{7

8

9}, Rodrigo Morales^{5

6}

Affiliations

¹ Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
² Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibanez, Santiago, Chile.
³ Departamento Biologia Celular, Genetica y Fisiologia, Facultad de Ciencias, Instituto de Investigacion Biomedica de Malaga-IBIMA, Universidad de Malaga, Málaga, Spain.
⁴ Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
⁵ Centro Integrativo de Biología y Química Aplicada, Universidad Bernardo O'Higgins, Santiago, Chile.
⁶ Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, United States.
⁷ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.
⁸ Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
⁹ Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

PMID: 35221985
PMCID: PMC8864239
DOI: 10.3389/fnagi.2021.830779

No abstract available

Keywords: Alzheimer's disease; aging; neurodegeneration; protein misfolding; proteostasis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Editorial on the Research Topic Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

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References

1. Auzmendi-Iriarte J., Matheu A. (2021). Impact of chaperone-mediated autophagy in brain aging: neurodegenerative diseases and glioblastoma. Front. Aging Neurosci. 12:509. 10.3389/fnagi.2020.630743 - DOI - PMC - PubMed
1. Gomez-Gutierrez R., Morales R. (2020). The prion-like phenomenon in Alzheimer's disease: evidence of pathology transmission in humans. PLoS Pathogens 16:e1009004. 10.1371/journal.ppat.1009004 - DOI - PMC - PubMed
1. Martinez G., Duran-Aniotz C., Cabral-Miranda F., Vivar J. P., Hetz C. (2017). Endoplasmic reticulum proteostasis impairment in aging. Aging Cell 16, 615–623. 10.1111/acel.12599 - DOI - PMC - PubMed
1. Martinez N. W., Gómez F. E., Matus S. (2021). The potential role of protein kinase R as a regulator of age-related neurodegeneration. Front. Aging Neurosci. 13:148. 10.3389/fnagi.2021.638208 - DOI - PMC - PubMed
1. Park K. W., Eun Kim G., Morales R., Moda F., Moreno-Gonzalez I., Concha-Marambio L., et al. . (2017). The endoplasmic reticulum chaperone GRP78/BiP modulates prion propagation in vitro and in vivo. Sci. Rep. 7:44723. 10.1038/srep44723 - DOI - PMC - PubMed

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Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

Affiliations

Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

Authors

Affiliations

Conflict of interest statement

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