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Review
. 2022 Feb 10:13:789882.
doi: 10.3389/fmicb.2022.789882. eCollection 2022.

The Complexity of SARS-CoV-2 Infection and the COVID-19 Pandemic

Maria Karoliny da Silva Torres  1   2 , Carlos David Araújo Bichara  1   2 , Maria de Nazaré do Socorro de Almeida  2   3 , Mariana Cayres Vallinoto  1   4 , Maria Alice Freitas Queiroz  1   2 , Izaura Maria Vieira Cayres Vallinoto  1 , Eduardo José Melo Dos Santos  2   3 , Carlos Alberto Marques de Carvalho  5 , Antonio Carlos R Vallinoto  1   2
Affiliations
Review

The Complexity of SARS-CoV-2 Infection and the COVID-19 Pandemic

Maria Karoliny da Silva Torres et al. Front Microbiol. .

Abstract

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the death of millions of people worldwide and thousands more infected individuals developed sequelae due to the disease of the new coronavirus of 2019 (COVID-19). The development of several studies has contributed to the knowledge about the evolution of SARS-CoV2 infection and the disease to more severe forms. Despite this information being debated in the scientific literature, many mechanisms still need to be better understood in order to control the spread of the virus and treat clinical cases of COVID-19. In this article, we carried out an extensive literature review in order to bring together, in a single article, the biological, social, genetic, diagnostic, therapeutic, immunization, and even socioeconomic aspects that impact the SAR-CoV-2 pandemic. This information gathered in this article will enable a broad and consistent reading of the main aspects related to the current pandemic.

Keywords: COVID-19; SARS-CoV-2; coronavirus; infection; pandemic.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Morphological structure, genome, and replication of SARS-CoV-2. (A) Viral genome. (B) Viral particle. (C) SARS-CoV-2 replication cycle.
FIGURE 2
FIGURE 2
Flowchart for identifying individuals possibly infected with the new coronavirus in the absence of laboratory tests.
See this image and copyright information in PMC

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