Confirmed reinfection with SARS-CoV-2 during a pregnancy: A case report

doi:10.1002/ccr3.5400

Case Reports

. 2022 Feb 15;10(2):e05400.

doi: 10.1002/ccr3.5400. eCollection 2022 Feb.

Confirmed reinfection with SARS-CoV-2 during a pregnancy: A case report

Verena Sengpiel^{1

2}, Ylva Carlsson^{1

2}, Jan-Åke Liljeqvist^{3

4}, Anders Elfvin^{5

6}, Ing-Marie Fyhr⁷, Anna Lundgren^{8

9}, Kristina Nyström^{10

11}, Mats Bemark^{8

9}, Magnus Gisslen^{11

4}, Johan Ringlander^{10

11}

Affiliations

¹ Region Västra Götaland Department of Obstetrics and Gynaecology Sahlgrenska University Hospital Gothenburg Sweden.
² Department of Obstetrics and Gynaecology, Institute for Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
³ Department of Infectious Diseases Institute of Biomedicine University of Gothenburg Gothenburg Sweden.
⁴ Region Västra Götaland Department of Infectious Diseases Sahlgrenska University Hospital Gothenburg Sweden.
⁵ Department of Paediatrics Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
⁶ Region Västra Götaland Department of Paediatrics Sahlgrenska University Hospital, Queen Silvia Children's Hospital Gothenburg Sweden.
⁷ Region Västra Götaland Department of Pathology Sahlgrenska University Hospital Gothenburg Sweden.
⁸ Department of Microbiology and Immunology Institute of Biomedicine University of Gothenburg Gothenburg Sweden.
⁹ Region Västra Götaland Department of Clinical Immunology and Transfusion Medicine Sahlgrenska University Hospital University of Gothenburg Gothenburg Sweden.
¹⁰ Region Västra Götaland Department of Clinical Microbiology Sahlgrenska University Hospital Gothenburg Sweden.
¹¹ Department of Infectious Diseases Institute of Biomedicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.

PMID: 35223007
PMCID: PMC8847408
DOI: 10.1002/ccr3.5400

Case Reports

Confirmed reinfection with SARS-CoV-2 during a pregnancy: A case report

Verena Sengpiel et al. Clin Case Rep. 2022.

. 2022 Feb 15;10(2):e05400.

doi: 10.1002/ccr3.5400. eCollection 2022 Feb.

Authors

Affiliations

¹ Region Västra Götaland Department of Obstetrics and Gynaecology Sahlgrenska University Hospital Gothenburg Sweden.
² Department of Obstetrics and Gynaecology, Institute for Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
³ Department of Infectious Diseases Institute of Biomedicine University of Gothenburg Gothenburg Sweden.
⁴ Region Västra Götaland Department of Infectious Diseases Sahlgrenska University Hospital Gothenburg Sweden.
⁵ Department of Paediatrics Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
⁶ Region Västra Götaland Department of Paediatrics Sahlgrenska University Hospital, Queen Silvia Children's Hospital Gothenburg Sweden.
⁷ Region Västra Götaland Department of Pathology Sahlgrenska University Hospital Gothenburg Sweden.
⁸ Department of Microbiology and Immunology Institute of Biomedicine University of Gothenburg Gothenburg Sweden.
⁹ Region Västra Götaland Department of Clinical Immunology and Transfusion Medicine Sahlgrenska University Hospital University of Gothenburg Gothenburg Sweden.
¹⁰ Region Västra Götaland Department of Clinical Microbiology Sahlgrenska University Hospital Gothenburg Sweden.
¹¹ Department of Infectious Diseases Institute of Biomedicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.

PMID: 35223007
PMCID: PMC8847408
DOI: 10.1002/ccr3.5400

Abstract

Pregnancy might impact immunity after SARS-CoV-2 infection and/or vaccination. We describe the first case of reinfection with SARS-CoV-2 during a pregnancy. While the mother lacked detectable antibodies 2 months after the first infection, both mother and baby had IgG antibodies at delivery. Infection did not cause any adverse pregnancy outcome.

Keywords: COVID‐19; SARS‐CoV‐2; case report; pregnancy; reinfection.

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Conflict of interest statement

MB has received materials, for testing of reagents for SARS‐CoV‐2 reactive T cells from Miltenyi. The reagents have not been used in the work of this manuscript. All other authors have nothing to declare.

Figures

**FIGURE 1**
Timeline of the pregnancy and postpartum period

**FIGURE 2**
SARS‐CoV‐2 sequence analysis. (A) Differences between sequences from first and second infections. (B) The blue bar indicates the first episode and the red bar indicates the second episode of COVID‐19 in a circular cladogram tree depicting SARS‐CoV‐2 strains circulating in Sweden during 2020. The strains from the two episodes cluster with disparate strains, strongly supporting infection with two different viral strains

See this image and copyright information in PMC

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References

1. Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta‐analysis. BMJ. 2020;370:m3320. - PMC - PubMed
1. Zambrano LD, Ellington S, Strid P, et al. Update: characteristics of symptomatic women of reproductive age with laboratory‐confirmed SARS‐CoV‐2 infection by pregnancy status ‐ United States, January 22‐October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(44):1641‐1647. - PMC - PubMed
1. Musa SS, Bello UM, Zhao S, Abdullahi ZU, Lawan MA, He D. Vertical transmission of SARS‐CoV‐2: a systematic review of systematic reviews. Viruses. 2021;13(9):1877. - PMC - PubMed
1. Walker KF, O'Donoghue K, Grace N, et al. Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG. 2020;127(11):1324‐1336. - PMC - PubMed
1. Norman M, Navér L, Söderling J. Association of maternal SARS‐CoV‐2 infection in pregnancy with neonatal outcomes. JAMA. 2021;325(20):2076‐2086. https://pubmed.ncbi.nlm.nih.gov/33914014/ - PMC - PubMed

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[1] Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta‐analysis. BMJ. 2020;370:m3320. - PMC - PubMed

[2] Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta‐analysis. BMJ. 2020;370:m3320. - PMC - PubMed

[3] Zambrano LD, Ellington S, Strid P, et al. Update: characteristics of symptomatic women of reproductive age with laboratory‐confirmed SARS‐CoV‐2 infection by pregnancy status ‐ United States, January 22‐October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(44):1641‐1647. - PMC - PubMed

[4] Zambrano LD, Ellington S, Strid P, et al. Update: characteristics of symptomatic women of reproductive age with laboratory‐confirmed SARS‐CoV‐2 infection by pregnancy status ‐ United States, January 22‐October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(44):1641‐1647. - PMC - PubMed

[5] Musa SS, Bello UM, Zhao S, Abdullahi ZU, Lawan MA, He D. Vertical transmission of SARS‐CoV‐2: a systematic review of systematic reviews. Viruses. 2021;13(9):1877. - PMC - PubMed

[6] Musa SS, Bello UM, Zhao S, Abdullahi ZU, Lawan MA, He D. Vertical transmission of SARS‐CoV‐2: a systematic review of systematic reviews. Viruses. 2021;13(9):1877. - PMC - PubMed

[7] Walker KF, O'Donoghue K, Grace N, et al. Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG. 2020;127(11):1324‐1336. - PMC - PubMed

[8] Walker KF, O'Donoghue K, Grace N, et al. Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG. 2020;127(11):1324‐1336. - PMC - PubMed

[9] Norman M, Navér L, Söderling J. Association of maternal SARS‐CoV‐2 infection in pregnancy with neonatal outcomes. JAMA. 2021;325(20):2076‐2086. https://pubmed.ncbi.nlm.nih.gov/33914014/ - PMC - PubMed

[10] Norman M, Navér L, Söderling J. Association of maternal SARS‐CoV‐2 infection in pregnancy with neonatal outcomes. JAMA. 2021;325(20):2076‐2086. https://pubmed.ncbi.nlm.nih.gov/33914014/ - PMC - PubMed

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Confirmed reinfection with SARS-CoV-2 during a pregnancy: A case report

Affiliations

Confirmed reinfection with SARS-CoV-2 during a pregnancy: A case report

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Conflict of interest statement

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