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Case Reports
. 2022 Feb 15;10(2):e05443.
doi: 10.1002/ccr3.5443. eCollection 2022 Feb.

Case report of penile cancer recurrence treated with cetuximab combined with anlotinib

Shuang Dai  1 , Yan-Yang Liu  1 , Tao Liu  2 , Yu Zhang  3 , De-Yun Luo  4
Affiliations
Case Reports

Case report of penile cancer recurrence treated with cetuximab combined with anlotinib

Shuang Dai et al. Clin Case Rep. .

Abstract

Penile squamous cell carcinoma with pelvic lymph node metastases/recurrence has a poor prognosis. We reported a case with recurrent pSCC was administered cetuximab and anlotinib after failure of first-line treatment and achieved an effective response. Cetuximab combined with anlotinib may be a new choice for relapsed pSCC.

Keywords: chemotherapy; metastases; penial squamous cell carcinoma; recurrence; targeted therapy.

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Conflict of interest statement

The author reports no conflict of interest in this work.

Figures

FIGURE 1
FIGURE 1
(A) Nest of invasive squamous cell carcinoma; (B) Histology of inguinal lymph node metastasis; (C) Finding squamous cell carcinoma in the dermis and subcutaneous fibrous adipose tissue; (D) Histology of the root of the penis metastasis. (A to D): H&E, 20X, respectively)
FIGURE 2
FIGURE 2
Treatment timeline after postoperative recurrence. (A) Left inguinal nodal metastasis; (B) Right inguinal nodal metastasis; (C1) Multiple adjacent tissue and organ metastases; (D1) Tumor progressed rapidly; (C2, D2, E2, F2) Fatty deposition; (E1) The right inguinal soft issue lesion shrank and the edema of right left reduced after two cycles of anlotinib and cetuximab. (F1,F3) Progression after stopping anlotinib and cetuximab
FIGURE 3
FIGURE 3
Edema of right leg. (A) is a pre‐treatment image; (B) is a post‐treatment image
See this image and copyright information in PMC

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