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Review
. 2022 Feb 23:10:20503121221077838.
doi: 10.1177/20503121221077838. eCollection 2022.

Role of circulating tumor DNA and circulating tumor cells in breast cancer: History and updates

Julien Chedid  1 , Sabine Allam  2 , Nathalie Chamseddine  1 , Maroun Bou Zerdan  3 , Clara El Nakib  3 , Hazem I Assi  3
Affiliations
Review

Role of circulating tumor DNA and circulating tumor cells in breast cancer: History and updates

Julien Chedid et al. SAGE Open Med. .

Abstract

Circulating tumor DNA, cell-free DNA, and circulating tumor cells have been at the epitome of recent research in breast cancer. These forms of liquid biopsies have been used in monitoring disease progression, estimating the risk of relapse, and response to treatment. Much has been done in relation to serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. Some studies have also explored their use in monitoring treatment response. As the field of liquid biopsies expands, more prospective studies are needed to tailor management in an individualistic approach. In this literature review, the authors explore the multiple uses of circulating tumor DNA and circulating tumor cells in breast cancer.

Keywords: Circulating tumor DNA; biomarkers; breast cancer; cell-free DNA; circulating tumor cells.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

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