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Case Reports
. 2022:27:e01456.
doi: 10.1016/j.idcr.2022.e01456. Epub 2022 Feb 19.

Clinical recrudescence of chronic untreated P. malariae infection after BNT162b2 CoVID-19 vaccine

G Ciusa  1   2 , F Guida Marascia  2 , R Virruso  3 , A Angheben  4 , G Guaraldi  1 , A Cascio  2
Affiliations
Case Reports

Clinical recrudescence of chronic untreated P. malariae infection after BNT162b2 CoVID-19 vaccine

G Ciusa et al. IDCases. 2022.

Abstract

We described a case of clinical reactivation of chronic P. malariae infection following CoVID-19 vaccination with BNT162b2 (Pifzer-Biontech CoVID-19 vaccine) in a 48-year old Italian man.The patient came to our attention for fever of unknown origin show a quartan pattern (every third day) associated to splenomegaly, the onset of the fever occurred one month after CoVID-19 vaccination with BNT162b2. P. malariae was diagnosed using Carestart™ malaria rapid test and Polymerase-Chain Reaction. Post-vaccine transient reduction of immune reactivity is described in literature, although the mechanism is unknown.

Keywords: BNT162b2; Chronic malaria; CoVID-19 vaccine; Malaria; Plasmodium malariae.

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Conflict of interest statement

None.

References

    1. 〈https://www.who.int/teams/global-malaria-programme/elimination/countries...〉.
    1. Boccolini D., Menegon M., Di Luca M., Toma L., Severini F., Marucci G., et al. Non-imported malaria in Italy: paradigmatic approaches and public health implications following an unusual cluster of cases in 2017. BMC Public Health. 2020;20(1):857. doi: 10.1186/s12889-020-08748-9. [PMID: 32503526; PMCID: PMC7275312] - DOI - PMC - PubMed
    1. Krogstad D.J. In: Mandell, Douglas and Bennett’s principles and practice of infectious disease. 4th ed. Mandell G.L., Bennett J.E., Dolin R., editors. Vol. 2. Churchill Livingstone; New York: 1995. Plasmodium species (malaria) pp. 2415–2427.
    1. Chadee D.D., Tilluckdharry C.C., Maharaj P., Sinanan C. Reactivation of Plasmodium malariae infection in a Trinidadian man after neurosurgery. N Engl J Med. 2000;342(25):1924. doi: 10.1056/NEJM200006223422520. - DOI - PubMed
    1. Vinetz J.M., Li J., McCutchan T.F., Kaslow D.C. Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly. N Engl J Med. 1998;338:367–371. - PubMed

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