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. 2022 Feb 9:10:816409.
doi: 10.3389/fped.2022.816409. eCollection 2022.

Severe Retinopathy of Prematurity Associated With Neurodevelopmental Disorder in Children

Young-Jin Choi  1 , Eun Hee Hong  2 , Yong Un Shin  2   3 , Gi Hwan Bae  4 , Inah Kim  4 , Heeyoon Cho  2   3
Affiliations

Severe Retinopathy of Prematurity Associated With Neurodevelopmental Disorder in Children

Young-Jin Choi et al. Front Pediatr. .

Abstract

Objective: This study aimed to investigate whether severe retinopathy of prematurity (ROP) could be an association factor for neurodevelopmental disorders in premature infants without other risk factors-such as congenital anomalies, birth injuries, and neurological diseases-that may cause developmental delay.

Methods: We used health claims data recorded between 2007 and 2018 in the Korean National Health Insurance Service (KNHIS) database. We recruited a total of 18,256 premature infant born between 2007 and 2008 without congenital anomaly or birth injury (with ROP 6,995, without ROP 11,261) and divided them into four groups as follows: Group A, 209 extremely premature infants [gestational age (GA) < 28] with mild ROP; Group B, 75 extremely premature infants (GA < 28) with severe ROP; Group C, 6,510 other premature infants (28 ≤ GA <37)with mild ROP; and Group D, 201 other premature infants (28 ≤ GA < 37) with severe ROP. Using regression analysis, we analyzed whether there was a correlation between ROP prevalence, severity, and developmental delay in premature infants without other risk factors.

Results: The prevalence of developmental delay, according to GA and ROP severity, was higher in patients with severe ROP than in the other patients. The prevalence gradually decreased after birth. Among extremely premature infants with ROP, those with severe ROP had a 3.082-fold higher association with neurodevelopmental complications than those with mild ROP (p < 0.001). Compared with other premature infants with ROP, those with severe ROP had a 3.269-fold higher association with neurodevelopmental complications than those with mild ROP.

Conclusion: The severity of ROP may be associated with neurodevelopmental disorders in premature infants.

Keywords: developmental delay; gestational age; neurodevelopmental disorders; premature infants; retinopathy of prematurity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Enrollment and grouping of study patients according to gestational age and retinopathy of prematurity severity. GA, gestational age. *Mild ROP: spontaneously healed without special treatment. **Severe ROP: underwent treatment for ROP.
Figure 2
Figure 2
Annual prevalence of overall neurodevelopmental complications among patients born between 2007 and 2008 with retinopathy of prematurity and treated, based on the Korean National Health Insurance Service database throughout the 10-year follow-up period.
See this image and copyright information in PMC

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