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. 2022 Feb 10:8:814519.
doi: 10.3389/fmed.2021.814519. eCollection 2021.

Comparison of a New Optical Biometer That Combines Scheimpflug Imaging With Partial Coherence Interferometry With That of an Optical Biometer Based on Swept-Source Optical Coherence Tomography and Placido-Disk Topography

Shihao Chen  1 , Qiaoyue Zhang  2 , Giacomo Savini  3 , Shuangzhe Zhang  1 , Xiaomin Huang  1 , Jinjin Yu  1 , Yirang Wang  1 , Rui Ning  1 , Jinhai Huang  1   4   5 , Ruixue Tu  1
Affiliations

Comparison of a New Optical Biometer That Combines Scheimpflug Imaging With Partial Coherence Interferometry With That of an Optical Biometer Based on Swept-Source Optical Coherence Tomography and Placido-Disk Topography

Shihao Chen et al. Front Med (Lausanne). .

Abstract

Purpose: To evaluate measurement precision and to compare the Pentacam AXL (Oculus Optikgeräte, Wetzlar, German), a new optical biometer based on Scheimpflug imaging and partial coherence interferometry (PCI) with that of the OA-2000 biometer (Tomey, Nagoya, Japan), which combines swept-source optical coherence tomography (SS-OCT) and Placido-disk topography.

Methods: Axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), aqueous depth (AQD), mean keratometry (Km), astigmatism vectors J0, J45, and corneal diameter (CD) were measured in triplicate by two technical operators. Within-subject standard deviation (Sw), repeatability and reproducibility (2.77 Sw), coefficient of variation (CoV), and intraclass correlation coefficient (ICC) were used to assess the Pentacam AXL intra-observer repeatability and inter-observer reproducibility. Paired t-test and Bland-Altman plots were used to determine the agreement between the two biometers.

Results: The new optical biometer had high intra-observer repeatability [all parameters evaluated had low CoV (<0.71%) and high ICC (>0.88)]. Inter-observer reproducibility was also excellent, with high ICC (>0.95) and low CoV (<0.52%). The 95% LoA between the new biometer and OA-2000 were insignificant for most of the parameters evaluated, especially for AL. However, the measurement agreement was moderate for CCT.

Conclusions: Intra-observer repeatability and inter-observer reproducibility were excellent for all parameters evaluated using the new optical biometer based on Scheimpflug imaging and PCI. There was a high agreement between the two devices and hence could be clinically interchangeable for the measurement of most ocular parameters.

Keywords: Scheimpflug imaging; agreement; repeatability; reproducibility; swept source optical coherence tomography.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Bland-Altman plots showing agreement between the new Scheimpflug imager in combination with partial coherence interferometry biometer and the swept-source optical coherence tomography-based biometer for measuring axial length. Solid lines represent the bias between the two devices and dotted lines represent the 95% confidence interval for the difference.
Figure 2
Figure 2
Bland-Altman plots showing agreement between the new Scheimpflug imager in combination with partial coherence interferometry biometer and the swept-source optical coherence tomography-based biometer for measuring central corneal thickness. Solid lines represent the bias between the two devices and dotted lines represent the 95% confidence interval for the difference.
Figure 3
Figure 3
Bland-Altman plots showing the agreement between the new Scheimpflug imager in combination with partial coherence interferometry biometer and the swept-source optical coherence tomography-based biometer for measuring aqueous depth. Solid lines represent the bias between the two devices and dotted lines represent the 95% confidence interval for the difference.
Figure 4
Figure 4
Bland-Altman plots showing the agreement between the new Scheimpflug imager in combination with partial coherence interferometry biometer and the swept-source optical coherence tomography-based biometer for measuring anterior chamber depth. Solid lines represent the bias between the two devices and dotted lines represent the 95% confidence interval for the difference.
Figure 5
Figure 5
Bland-Altman plots showing the agreement between the new Scheimpflug imager in combination with partial coherence interferometry biometer and the swept-source optical coherence tomography-based biometer for measuring mean keratometry at 3.0 mm. Solid lines represent the bias between the two devices and dotted lines represent the 95% confidence interval for the difference.
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