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Review
. 2022 Feb 10:3:822824.
doi: 10.3389/froh.2022.822824. eCollection 2022.

Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review

Leonardo Mancini  1   2 , Lorenzo Maria Americo  1   2 , Tommaso Pizzolante  1   2 , Raffaele Donati  3 , Enrico Marchetti  1   2
Affiliations
Review

Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review

Leonardo Mancini et al. Front Oral Health. .

Abstract

COVID-19 is reported as one of the most widespread diseases in the world. An extraordinary number of articles and manuscripts have focused on the inflammatory cascade and sequelae, showing the important roles of cytokines and renin-angiotensin levels and possible links to other pathologies. Nowadays, interest regarding the possible correlation between COVID-19 and periodontal and Peri-implant diseases is increasing. This mini-review aims to collect data regarding the possible correlation between COVID-19 and periodontitis or Peri-implantitis through the analysis of articles published in the last 3 years. The following keywords were used: ([periodontitis OR periodontal disease] AND [COVID-19]); ([Peri-implantitis OR mucositis] AND [COVID-19 OR Sars-CoV-2]). The inclusion criteria were studies on COVID-19 or SARS-CoV-2 and periodontitis or Peri-implantitis, and studies on the molecular and cellular aspect of COVID-19 in periodontal or Peri-implant tissues. The search revealed 484 articles in total (PubMed 208 and Scopus 276). After a screening of titles and abstracts, 47 articles were included in the full-text analysis. Two articles comprised the Peri-implant group: a short communication and a review. Regarding the periodontal group, 45 articles were selected and analyzed according to the type of study, population, and aim. Of these, 10 articles were clinical studies, and the other 35 were hypotheses, reviews, letters to the editor, or commentaries. In conclusion, according to the data extracted, a mutual correlation between COVID-19 and periodontitis can be stated; however, data linked to Peri-implantitis are still missing, and future clinical studies are still needed.

Keywords: ACE-2; COVID-19; bone remodeling; cytokines; inflammation; peri-implantitis; periodontitis.

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Conflict of interest statement

LM, LA, TP, and EM were employed by PerioAQ Group. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart for the inclusion and exclusion process.
Figure 2
Figure 2
Representation of evidence regarding a possible correlation between Periodontitis/Peri-implantitis and COVID-19.
See this image and copyright information in PMC

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