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. 2022 Apr;46(4):543-545.
doi: 10.1111/aor.14203. Epub 2022 Feb 28.

First successful porcine to human heart transplantation performed in the United States

Aakash M Shah, Jason J Han

First successful porcine to human heart transplantation performed in the United States

Aakash M Shah et al. Artif Organs. 2022 Apr.

Abstract

In an 8-h operation, the cardiac surgery team at the University of Maryland Medical Center made history by performing the first porcine-to-human heart transplant without signs of early rejection. Xenotransplantation offers a potential solution to the thousands of patients worldwide who die annually while waiting for donor organs.

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References

FURTHER READING

    1. Mohiuddin M, Goerlich C, Singh A, Zhang T, Tatarov I, Lewis B, et al. Progressive genetic modifications with growth hormone receptor knockout extends cardiac Xenograft survival to 9 months. Res Sq. 2021;Preprint.
    1. Cooley DA, Hallman GL, Bloodwell RD, Nora JJ, Leachman RD. Human heart transplantation. Experience with twelve cases. Am J Cardiol. 1968;22(6):804-10.
    1. Cooper DKC. Genetically engineered pig kidney transplantation in a brain-dead human subject. Xenotransplantation. 2021;28(6):e12718.
    1. Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat Commun. 2016;7:11138.
    1. OPTN. National data. Available from: https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/#

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