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. 1986 Jul;167(1):383-6.
doi: 10.1128/jb.167.1.383-386.1986.

Role of leader peptide synthesis in tryptophanase operon expression in Escherichia coli K-12

V Stewart, C Yanofsky

Role of leader peptide synthesis in tryptophanase operon expression in Escherichia coli K-12

V Stewart et al. J Bacteriol. 1986 Jul.

Abstract

We used site-directed mutagenesis to replace the Escherichia coli tryptophanase (tna) operon leader peptide start codon with AUC. This change greatly decreased the uninduced rate of tna operon expression, and it also lowered the response to inducer. We conclude that leader peptide synthesis plays an essential role in tna operon expression.

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