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. 2022 Feb 28;33(3):26.
doi: 10.1007/s10856-021-06574-y.

OXA-CuS@UiO-66-NH2 as a drug delivery system for Oxaliplatin to colorectal cancer cells

Marjan Gholami  1 , Azadeh Hekmat  1 , Majid Khazaei  2 , Majid Darroudi  3   4
Affiliations

OXA-CuS@UiO-66-NH2 as a drug delivery system for Oxaliplatin to colorectal cancer cells

Marjan Gholami et al. J Mater Sci Mater Med. .

Abstract

In this work, UiO-66-NH2 was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH2. To characterize and investigate their cytotoxicity effects, powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) analysis, UV-Visible analysis, inductively coupled plasma mass spectrometry (ICP-MS), and MTT assay were considered to be performed. According to the observations, the cytotoxicity of OXA-CuS@UiO-66-NH2 was greater than that of the OXA alone.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PXRD of UiO-66-NH2, CuS, CuS@UiO-66-NH2, and OXA-CuS@UiO-66-NH2
Fig. 2
Fig. 2
FTIR Spectra of CuS, UiO-66-NH2, Cus@-UiO-66-NH2, and OXA-CuS@UiO-66-NH2
Fig. 3
Fig. 3
The BET analysis of samples
Fig. 4
Fig. 4
FESEM images and size distributions of the UiO-66-NH2, CuS@UiO-66-NH2, and OXA-CuS@UiO-66-NH2
Fig. 5
Fig. 5
DLS distribution in water and growth medium of UiO-66-NH2, CuS@UiO-66-NH2, and OXA-CuS@UiO-66-NH2
Fig. 6
Fig. 6
MTT assay of CuS, OXA, CuS@UiO-66, OXA@UiO-66-NH2, and OXA-CuS@UiO-66-NH2
Fig. 7
Fig. 7
Flow cytometry charts of UiO-66-NH2 and OXA-CuS@UiO-66-NH2 (a and b) and statistics (c)
See this image and copyright information in PMC

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