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Review
. 2022 Mar 1;23(3):e189-e204.
doi: 10.1542/neo.23-3-e189.

Fluid Homeostasis and Diuretic Therapy in the Neonate

Cara Slagle  1 , Katja M Gist  2 , Michelle C Starr  3 , Trina S Hemmelgarn  4 , Stuart L Goldstein  5 , Alison L Kent  6
Affiliations
Review

Fluid Homeostasis and Diuretic Therapy in the Neonate

Cara Slagle et al. Neoreviews. .

Abstract

Understanding physiologic water balance and homeostasis mechanisms in the neonate is critical for clinicians in the NICU as pathologic fluid accumulation increases the risk for morbidity and mortality. In addition, once this process occurs, treatment is limited. In this review, we will cover fluid homeostasis in the neonate, explain the implications of prematurity on this process, discuss the complexity of fluid accumulation and the development of fluid overload, identify mitigation strategies, and review treatment options.

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Conflict of interest statement

AUTHOR DISCLOSURE Drs Slagle, Gist, Starr, Hemmelgarn, Goldstein, and Kent have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.

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