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Review
. 2022 Feb;5(1):27-37.
doi: 10.1002/ame2.12209. Epub 2022 Jan 27.

Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective

Rajashree Banerjee  1 , Arushi Rai  1 , Shreyas M Iyer  1 , Sonia Narwal  1 , Meghana Tare  1
Affiliations
Review

Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective

Rajashree Banerjee et al. Animal Model Exp Med. 2022 Feb.

Abstract

Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are largely sporadic in nature. Although the advances in our understanding of the two have been significant, they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful. Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research. This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease, and highlights the shifting paradigms in studying two human-specific conditions in non-human organisms.

Keywords: Alzheimer's disease; Parkinson's disease; animal models; neurodegeneration.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Clinical and pathological overlap between AD and PD
See this image and copyright information in PMC

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References

    1. GBD 2019 Diseases and Injuries Collaborators . Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1204‐1222. doi: 10.1016/S0140-6736(20)30925-9 - DOI - PMC - PubMed
    1. Weller J, Budson A. Current understanding of Alzheimer's disease diagnosis and treatment. F1000Res. 2018;7:F1000 Faculty Rev‐1161. doi: 10.12688/f1000research.14506.1 - DOI
    1. Rizek P, Kumar N, Jog MS. An update on the diagnosis and treatment of Parkinson disease. CMAJ. 2016;188(16):1157‐1165. doi: 10.1503/cmaj.151179 - DOI - PMC - PubMed
    1. McDade E, Bateman RJ. Stop Alzheimer's before it starts. Nature. 2017;547(7662):153‐155. doi: 10.1038/547153a - DOI - PubMed
    1. Lang AE, Espay AJ. Disease modification in Parkinson's disease: current approaches, challenges, and future considerations. Mov Disord. 2018;33(5):660‐677. doi: 10.1002/mds.27360 - DOI - PubMed

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