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. 2022 Aug;18(6):2195-2201.
doi: 10.1007/s12015-022-10357-5. Epub 2022 Mar 1.

Artificial Mitochondrial Transfer (AMT) for the Management of Age-related Musculoskeletal Degenerative Disorders: An Emerging Avenue for Bone and Cartilage Metabolism Regulation

Lynda Bourebaba  1   2 , Katarzyna Kornicka-Garbowska  1   2 , Larry Galuppo  3 , Krzysztof Marycz  4   5   6
Affiliations

Artificial Mitochondrial Transfer (AMT) for the Management of Age-related Musculoskeletal Degenerative Disorders: An Emerging Avenue for Bone and Cartilage Metabolism Regulation

Lynda Bourebaba et al. Stem Cell Rev Rep. 2022 Aug.

Abstract

Musculoskeletal system disorders are among the most common age-related conditions worldwide. All associated with a degeneration of the supporting tissues under pro-inflammatory micro- and macro-environments, the erosion of cartilage and later of bones, are the main hallmarks of these pathologies. Affected chondrocytes, osteoblasts and synoviocytes, that are all critical actors in the bone and cartilage defects exhibit mitochondrial dysfunction that develops immediately following cartilage and bone injury, and leads to tissue residing specific cell death, cartilage degeneration, bone erosion, and ultimately post-traumatic musculoskeletal degeneration. Herein, we would like to introduce a novel concept for bone and cartilage related defects treatment based on artificial transfer of exogeneous functional mitochondria (AMT). Particularly, we believe that because mitochondrial failure critically contributes to degenerative disorders onset and progression, replacing malfunctioning mitochondria with their healthy and functional counterparts can represent a novel, and effective therapeutic solution for the management of bone and cartilage related degenerative diseases. Artificial mitochondrial transfer (AMT) may reverse the failed metabolic status of musculoskeletal tissues cells and reduce bone and cartilage tissues defects by restoring mitochondrial bioenergetics.

Keywords: ATM; Aging; Bone defect; Mitochondrial Dysfunction; OXPHOS; Synovitis.

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References

    1. Lashkari, M. H., Shekarchi, B., & Soltani, M. (2014). Joint degenerative disorder epidemiology in military patients by MRI and comparison with civilian patients. Biosciences Biotechnology Research Asia, 11(2), 767–771. https://doi.org/10.13005/bbra/1334
    1. Li, B., & Chen, D. (2019). Degenerative musculoskeletal diseases: Pathology and treatments. Journal of Orthopaedic Translation, 17, 1–2. https://doi.org/10.1016/j.jot.2019.05.001 - DOI - PubMed - PMC
    1. Rego-Pérez, I., Durán-Sotuela, A., Ramos-Louro, P., & Blanco, F. J. (2020). Mitochondrial Genetics and Epigenetics in Osteoarthritis. Frontiers in Genetics, 10, 1335. https://doi.org/10.3389/fgene.2019.01335 - DOI - PubMed - PMC
    1. Hunter, D. J., & Sambrook, P. N. (2000). No title found. Arthritis Research, 2(6), 441. https://doi.org/10.1186/ar125 - DOI - PubMed - PMC
    1. Komatsu, N., & Takayanagi, H. (2012). Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal Cells in Joints. Frontiers in Immunology, 3. https://doi.org/10.3389/fimmu.2012.00077 - DOI

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