Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;42(5):1204-1205.
doi: 10.1111/liv.15224. Epub 2022 Mar 11.

Autoimmune hepatitis or drug-induced autoimmune hepatitis following Covid-19 vaccination?

Federica Fimiano  1 , Daphne D'Amato  1 , Alessandro Gambella  2 , Alfredo Marzano  1 , Giorgio M Saracco  1 , Anna Morgando  1
Affiliations

Autoimmune hepatitis or drug-induced autoimmune hepatitis following Covid-19 vaccination?

Federica Fimiano et al. Liver Int. 2022 May.
No abstract available

Keywords: Covid-19 vaccine; autoimmune hepatitis; drug-induced autoimmune hepatitis.

PubMed Disclaimer

Conflict of interest statement

The authors do not have any disclosures to report.

Figures

FIGURE 1
FIGURE 1
Acute hepatitis with lymphoplasmacytic‐rich inflammatory infiltrate. The biopsy showed a severe hepatic injury with intense portal/periportal lymphoplasmacytic infiltrate and interface hepatitis (A; haematoxylin and eosin, original magnification 200×). Lobular inflammation, centrilobular congestion, and confluent necrosis were also noticed (B, C; haematoxylin and eosin, original magnification 200×). Immunohistochemical staining for CD138 (D; original magnification 200×) highlighted plasma cells infiltrate with diffuse involvement of portal tract interface (black arrows)
See this image and copyright information in PMC

References

    1. Bril F, Al Diffalha S, Dean M, Fettig DM. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID‐19) vaccine: causality or casualty? J Hepatol. 2021;75:222‐224. - PMC - PubMed
    1. Tan CK, Wong YJ, Wang LM, Ang TL, Kumar R. Autoimmune hepatitis following COVID‐19 vaccination: true causality or mere association? J Hepatol. 2021;75:1250‐1252. doi:10.1016/j.jhep.2021.06.009 - DOI - PMC - PubMed
    1. McShane C, Kiat C, Rigby J, Crosbie Ó. The mRNA COVID‐19 vaccine – a rare trigger of autoimmune hepatitis? J Hepatol. 2021;75:1252‐1254. doi:10.1016/j.jhep.2021.06.044 - DOI - PMC - PubMed
    1. Ghielmetti M, Schaufelberger HD, Mieli‐Vergani G, et al. Acute autoimmune‐like hepatitis with atypical anti‐mitochondrial antibody after mRNA COVID‐19 vaccination: a novel clinical entity? J Autoimmun. 2021;123:102706. - PMC - PubMed
    1. Zin Tun GS, Gleeson D, Al‐Joudeh A, Dube A. Immune‐mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed. J Hepatol. 2022;76:747‐749. - PMC - PubMed

Substances