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. 2022 May;101(5):1073-1076.
doi: 10.1016/j.kint.2022.02.011. Epub 2022 Feb 26.

A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients

Ilies Benotmane  1 , Timothée Bruel  2 , Delphine Planas  2 , Samira Fafi-Kremer  3 , Olivier Schwartz  2 , Sophie Caillard  4
Affiliations

A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients

Ilies Benotmane et al. Kidney Int. 2022 May.
No abstract available

Keywords: Delta variant; SARS-CoV-2; fourth dose; kidney transplantation; mRNA vaccine; neutralizing antibodies.

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Figures

Figure 1
Figure 1
(a) Anti–receptor-binding domain (RBD) antibody titers after the third and fourth doses of the mRNA-1273 (Moderna) vaccine in 67 kidney transplant recipients. A titer of >7.1 binding antibody units (BAUs)/ml was regarded as positive (dotted line), whereas a titer of <143 BAUs/ml was considered to reflect a weak humoral response (black line). The percentages of patients with titers above 143 BAUs/ml before and after the fourth dose are shown in the graph. Blue lines represent patients with a titer of >143 BAUs/ml, whereas red lines denote patients with a titer of <143 BAUs/ml after the fourth dose. (b) Neutralizing inhibitory dilution 50 (ID50) against the Delta variant after the third and fourth doses of the mRNA-1273 (Moderna) vaccine in 67 kidney transplant recipients. Neutralizing antibodies were expressed as the concentration capable of inhibiting 50% of the virus inoculum (ID50; limit of detection 7.5; dotted line). A neutralizing ID50 of >30 was considered as positive (black line). The percentages of patients showing neutralizing activity against the Delta variant before and after the fourth dose are shown in the graph. Blue lines represent patients with a neutralizing ID50 of >30, whereas red lines denote patients with a neutralizing ID50 of <30 after the fourth dose. (c) Scattergram and regression line showing a significant positive correlation between anti-RBD IgG antibody titers (log BAUs/ml) and neutralizing ID50 against the Delta strain (log ID50) before and after the fourth dose of the mRNA-1273 (Moderna) vaccine in 67 kidney transplant recipients (Pearson r2 = 0.54; P < 0.0001). The dotted line parallel to the y axis represents the cutoff for a positive neutralizing ID50 titer (30), whereas the dotted line parallel to the x axis represents the cutoff for a weak RDB IgG antibody titer (143 BAUs/ml).
See this image and copyright information in PMC

References

    1. Benotmane I., Gautier G., Perrin P., et al. Antibody response after a third dose of the mRNA-1273 SARS-CoV-2 vaccine in kidney transplant recipients with minimal serologic response to 2 doses. JAMA. 2021;326:1063–1065. - PMC - PubMed
    1. Hall V.G., Ferreira V.H., Ku T., et al. Randomized trial of a third dose of mRNA-1273 vaccine in transplant recipients. N Engl J Med. 2021;385:1244–1246. - PMC - PubMed
    1. Subbaraman N. How do vaccinated people spread Delta? What the science says. https://www.nature.com/articles/d41586-021-02187-1 - PubMed
    1. Planas D., Veyer D., Baidaliuk A., et al. Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization. Nature. 2021;596:276–280. - PubMed
    1. Lopez Bernal J., Andrews N., Gower C., et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N Engl J Med. 2021;385:585–594. - PMC - PubMed

Supplementary concepts