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. 2023 May;44(5):798-801.
doi: 10.1017/ice.2022.37. Epub 2022 Mar 2.

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) exposure investigations using genomic sequencing among healthcare workers and patients in a large academic center

Leigh Smith #  1   2 , C Paul Morris #  3   4 , Morgan H Jibowu  2 , Susan Fallon  2 , Stuart C Ray  1 , Sara E Cosgrove  1   2 , Melanie S Curless  2 , Valeria Fabre  1   2 , Sara M Karaba  1 , Lisa L Maragakis  1   2 , Aaron M Milstone  2   5 , Anna C Sick-Samuels  2   5 , Polly Trexler  2 , Heba H Mostafa #  3 , Clare Rock #  1   2 ; CDC Prevention Epicenter Program
Affiliations

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) exposure investigations using genomic sequencing among healthcare workers and patients in a large academic center

Leigh Smith et al. Infect Control Hosp Epidemiol. 2023 May.

Abstract

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) transmissions among healthcare workers and hospitalized patients are challenging to confirm. Investigation of infected persons often reveals multiple potential risk factors for viral acquisition. We combined exposure investigation with genomic analysis confirming 2 hospital-based clusters. Prolonged close contact with unmasked, unrecognized infectious, individuals was a common risk.

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Figures

Fig. 1.
Fig. 1.
COVID-19 clusters involving healthcare workers, patients and visitor: relative timing of symptom onset, testing, and viral burden.
Fig. 2.
Fig. 2.
Phylogenetic representation of relationships of sequences from cluster one (red) and cluster two (blue) to all sequences from clade 20G at Johns Hopkins Hospital.
See this image and copyright information in PMC

Comment in

References

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