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Review
. 2022 Apr 1;27(2):126-130.
doi: 10.1097/MOT.0000000000000966.

Current review on the role of ileostomy following intestinal transplantation

Robert S Venick  1
Affiliations
Review

Current review on the role of ileostomy following intestinal transplantation

Robert S Venick. Curr Opin Organ Transplant. .

Abstract

Purpose of review: This review describes the historical rationale for ostomy creation at the time of intestinal transplantation (ITx), examines the utility of endoscopy in graft monitoring, details the limitations and potential complications of endoscopy in this patient population, highlights preliminary reports of ITx without surveillance biopsy or stoma formation, and emphasizes the importance of novel biomarkers for graft monitoring. Data will be discussed from contemporary publications in the field, as well as the Intestinal Transplant Registry.

Recent findings: Significant improvements have been made in early outcomes following ITx, yet long-term survival remains challenged by rejection. Although endoscopy and biopsy are the gold-standard for graft monitoring, some centers have performed ITx recently without surveillance endoscopy or stoma formation with similar success. Others have touted the need for less-invasive, timely and accurate biomarkers as essential to help improve results.

Summary: The review provides a thorough overview of the emerging debate in the field of ITx regarding the importance of surveillance endoscopy and stoma formation in ITx recipients.

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References

    1. Grant D, Abu-Elmagd K, Mazariegos G, et al. Intestinal transplant registry report: global activity and trends. Am J Transplant 2015; 15:210–219.
    1. Smith JM, Weaver T, Skeans A, et al. OPTN/SRTR 2017 annual data report: intestine. Am J Transplant 2019; 2:284–322.
    1. Raghu VK, Beaumont JL, Everly MJ, et al. Pediatric intestinal transplantation: analysis of the intestinal transplant registry. Pediatr Transplant 2019; 23:e13580.
    1. Venick RS, Duggan E, Whatley J. Current status of pediatric intestinal transplantation in the United States. Curr Opin Organ Transplant 2020; 25:201–207.
    1. Venick RS. Long term results of intestinal transplantation in children: survival after 10 years, intestinal function, quality of life. Curr Opin Organ Transplant 2018; 23:219–223.

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