The Role of Insular Cortex in Gut-Inflammation Memory: What Does It Mean for Parkinson's Disease?

Affiliations

¹ Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

Comment

Diana A Olszewska et al. Mov Disord. 2022 Apr.

. 2022 Apr;37(4):700-701.

doi: 10.1002/mds.28975. Epub 2022 Mar 1.

¹ Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

No abstract available

Comment on

Insular cortex neurons encode and retrieve specific immune responses.
Koren T, Yifa R, Amer M, Krot M, Boshnak N, Ben-Shaanan TL, Azulay-Debby H, Zalayat I, Avishai E, Hajjo H, Schiller M, Haykin H, Korin B, Farfara D, Hakim F, Kobiler O, Rosenblum K, Rolls A. Koren T, et al. Cell. 2021 Nov 24;184(24):5902-5915.e17. doi: 10.1016/j.cell.2021.10.013. Epub 2021 Nov 8. Cell. 2021. PMID: 34752731

1. Koren T, Yifa R, Amer M, et al. Insular cortex neurons encode and retrieve specific immune responses. Cell 2021;184(24):5902-5915.e17.
1. Menozzi E, Macnaughtan J, Schapira AHV. The gut-brain axis and Parkinson disease: clinical and pathogenetic relevance. Ann Med 2021;53(1):611-625.
1. Peter I, Dubinsky M, Bressman S, et al. Anti-tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease. JAMA Neurol 2018;75(8):939-946.
1. Lin CH, Lin HY, Ho EP, et al. Mild chronic colitis triggers parkinsonism in LRRK2 mutant mice through activating TNF-α pathway. Mov Disord 2022;37(4):745-757. https://doi.org/10.1002/mds.28890
1. Chen QQ, Haikal C, Li W, Li JY. Gut inflammation in association with pathogenesis of Parkinson's disease. Front Mol Neurosci 2019;12:218