Hepatic clearance models and IVIVE predictions

Affiliations

¹ Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
² Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

Comment

Malcolm Rowland et al. Clin Pharmacol Ther. 2022 Jun.

. 2022 Jun;111(6):1205-1207.

doi: 10.1002/cpt.2525. Epub 2022 Mar 1.

¹ Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
² Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

No abstract available

Comment on

Can In Vitro-In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions.
Benet LZ, Sodhi JK. Benet LZ, et al. Clin Pharmacol Ther. 2022 May;111(5):1022-1035. doi: 10.1002/cpt.2482. Epub 2021 Dec 8. Clin Pharmacol Ther. 2022. PMID: 34731496 Free PMC article. Review.

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