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. 1986 Jul;83(13):4942-6.
doi: 10.1073/pnas.83.13.4942.

Odorant-binding protein: localization to nasal glands and secretions

J Pevsner, P B Sklar, S H Snyder

Odorant-binding protein: localization to nasal glands and secretions

J Pevsner et al. Proc Natl Acad Sci U S A. 1986 Jul.

Abstract

An odorant-binding protein (OBP) was isolated from bovine olfactory and respiratory mucosa. We have produced polyclonal antisera to this protein and report its immunohistochemical localization to mucus-secreting glands of the olfactory and respiratory mucosa. Although OBP was originally isolated as a pyrazine binding protein, both rat and bovine OBP also bind the odorants [3H]methyldihydrojasmonate and 3,7-dimethyl-octan-1-ol as well as 2-isobutyl-3-[3H]methoxypyrazine. We detect substantial odorant-binding activity attributable to OBP in secreted rat nasal mucus and tears but not in saliva, suggesting a role for OBP in transporting or concentrating odorants.

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