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. 2022 Jun 15;35(1):ivac053.
doi: 10.1093/icvts/ivac053.

Transapical beating heart mitral valve repair versus conventional surgery: a propensity-matched study

A D'Onofrio  1 , F Mastro  1 , M Nadali  1 , A Fiocco  1 , D Pittarello  2 , P Aruta  3 , G Evangelista  1 , G Lorenzoni  4 , D Gregori  4 , G Gerosa  1
Affiliations

Transapical beating heart mitral valve repair versus conventional surgery: a propensity-matched study

A D'Onofrio et al. Interact Cardiovasc Thorac Surg. .

Abstract

Objectives: Transapical Neochordae implantation (NC) allows beating heart mitral valve repair in patients with degenerative mitral regurgitation. The aim of this single-centre, retrospective study was to compare outcomes of NC versus conventional surgical (CS) mitral valve repair.

Methods: Data of patients who underwent isolated mitral valve repair with NC or CS from January 2010 to December 2018 were collected. A propensity score matching analysis was performed to reduce confounding due to baseline differences between groups. The primary end point was overall all-cause mortality; secondary end points were freedom from reoperation, freedom from moderate (2+) and from severe (3+) mitral regurgitation (MR) and New York Heart Association functional class in the overall population and in patients with isolated P2 prolapse (type A anatomy).

Results: Propensity analysis selected 88 matched pairs. There was no 30-day mortality in the 2 groups. Kaplan-Meier analysis showed similar 5-year survival in the 2 groups. Patients undergoing NC showed worse freedom from moderate MR (≥2+) (57.6% vs 84.6%; P < 0.001) and from severe MR (3+) at 5-year follow-up: 78.1% vs 89.7% (P = 0.032). In patients with type A anatomy, freedom from moderate MR and from severe MR was similar between groups (moderate: 63.9% vs 74.6%; P = 0.21; severe: 79.3% vs 79%; P = 0.77 in NC and FS, respectively). Freedom from reoperation was lower in the NC group: 78.9% vs 92% (P = 0.022) but, in type A patients, it was similar: 79.7% and 85% (P = 0.75) in the NC and CS group, respectively. More than 90% of patients of both groups were in New York Heart Association class I and II at follow-up.

Conclusions: Transapical beating-heart mitral chordae implantation can be considered as an alternative treatment to CS, especially in patients with isolated P2 prolapse.

Keywords: Mitral valve repair; Surgical; Transapical.

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Figures

Figure 1:
Figure 1:
Neochord DS 1000 device (A) and appropriate leaflet grasping confirmed either by transoesophageal echocardiography imaging and by the 4 device lights turning white (B).
Figure 2:
Figure 2:
Overall survival in the matched cohort (A) and in type A patients (B).
Figure 3:
Figure 3:
Freedom from moderate mitral (2+) regurgitation in the matched cohort (A) and in type A patients (B).
Figure 4:
Figure 4:
Freedom from reoperation in the matched cohort (A) and in type A patients (B).
Figure 5:
Figure 5:
New York Heart Association functional class at baseline and at follow-up in patients undergoing conventional surgery and Neochord operation.
None
See this image and copyright information in PMC

Comment in

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