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Review
. 2022 Jun;49(6):4943-4957.
doi: 10.1007/s11033-022-07132-7. Epub 2022 Mar 2.

Current advances and challenges in COVID-19 vaccine development: from conventional vaccines to next-generation vaccine platforms

Ameneh Jafari  1   2 , Fahima Danesh Pouya  3 , Zahra Niknam  2 , Meghdad Abdollahpour-Alitappeh  4   5 , Mostafa Rezaei-Tavirani  6 , Yousef Rasmi  3   7
Affiliations
Review

Current advances and challenges in COVID-19 vaccine development: from conventional vaccines to next-generation vaccine platforms

Ameneh Jafari et al. Mol Biol Rep. 2022 Jun.

Abstract

The world is grappling with an unprecedented public health crisis COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2. Due to the high transmission/mortality rates and socioeconomic impacts of the COVID-19, its control is crucial. In the absence of specific treatment, vaccines represent the most efficient way to control and stop the pandemic. Many companies around the world are currently making efforts to develop the vaccine to combat COVID-19. This review outlines key strategies for generating SARS-CoV-2 vaccine candidates, along with the mechanism of action, advantages, and potential limitations of each vaccine. The use of nanomaterials and nanotechnology for COVID-19 vaccines development will also be discussed.

Keywords: COVID -19 vaccine platform; Nanoparticles-based vaccine; SARS-CoV-2; Vaccine candidate; Vaccine efficacy.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Fig. 1
Fig. 1
The vaccine platforms for COVID-19 vaccine development (Created with BioRender.com)
Fig. 2
Fig. 2
The different mechanisms of COVID-19 vaccine platforms
See this image and copyright information in PMC

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