Protective and pathogenic role of humoral responses in COVID-19

doi:10.1007/s12275-022-2037-8

Review

. 2022 Mar;60(3):268-275.

doi: 10.1007/s12275-022-2037-8. Epub 2022 Mar 2.

Protective and pathogenic role of humoral responses in COVID-19

Uni Park^{1

2}, Nam-Hyuk Cho^{3

4

5

6

7}

Affiliations

¹ Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
² Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
³ Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. chonh@snu.ac.kr.
⁴ Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. chonh@snu.ac.kr.
⁵ Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, 03080, Republic of Korea. chonh@snu.ac.kr.
⁶ Seoul National University Bundang Hospital, Seongnam, 13620, Republic of Korea. chonh@snu.ac.kr.
⁷ Wide River Institute of Immunology, Seoul National University, Hongcheon, 25159, Republic of Korea. chonh@snu.ac.kr.

PMID: 35235178
PMCID: PMC8890013
DOI: 10.1007/s12275-022-2037-8

Review

Protective and pathogenic role of humoral responses in COVID-19

Uni Park et al. J Microbiol. 2022 Mar.

. 2022 Mar;60(3):268-275.

doi: 10.1007/s12275-022-2037-8. Epub 2022 Mar 2.

Authors

Uni Park^{1

2}, Nam-Hyuk Cho^{3

4

5

6

7}

Affiliations

¹ Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
² Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
³ Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. chonh@snu.ac.kr.
⁴ Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. chonh@snu.ac.kr.
⁵ Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, 03080, Republic of Korea. chonh@snu.ac.kr.
⁶ Seoul National University Bundang Hospital, Seongnam, 13620, Republic of Korea. chonh@snu.ac.kr.
⁷ Wide River Institute of Immunology, Seoul National University, Hongcheon, 25159, Republic of Korea. chonh@snu.ac.kr.

PMID: 35235178
PMCID: PMC8890013
DOI: 10.1007/s12275-022-2037-8

Erratum in

Erratum to: Protective and Pathogenic Role of Humoral Responses in COVID-19.
Park U, Cho NH. Park U, et al. J Microbiol. 2023 Jul;61(7):713. doi: 10.1007/s12275-023-00058-0. J Microbiol. 2023. PMID: 37530961 Free PMC article. No abstract available.

Abstract

Since the advent of SARS-CoV-2 in Dec. 2019, the global endeavor to identify the pathogenic mechanism of COVID-19 has been ongoing. Although humoral immunity including neutralizing activity play an important role in protection from the viral pathogen, dysregulated antibody responses may be associated with the pathogenic progression of COVID-19, especially in high-risk individuals. In addition, SARS-CoV-2 spike-specific antibodies acquired by prior infection or vaccination act as immune pressure, driving continuous population turnover by selecting for antibody-escaping mutations. Here, we review accumulating knowledge on the potential role of humoral immune responses in COVID-19, primarily focusing on their beneficial and pathogenic properties. Understanding the multifaceted regulatory mechanisms of humoral responses during SARS-CoV-2 infection can help us to develop more effective therapeutics, as well as protective measures against the ongoing pandemic.

Keywords: COVID-19; SARS-CoV-2; antibody-escaping variants; humoral immunity.

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References

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[1] Abdulrahman A, Mallah SI, Alqahtani M. COVID- 19 viral load not associated with disease severity: findings from a retrospective cohort study. BMC Infect. Dis. 2021;21:688. doi: 10.1186/s12879-021-06376-1. - DOI - PMC - PubMed

[2] Abdulrahman A, Mallah SI, Alqahtani M. COVID- 19 viral load not associated with disease severity: findings from a retrospective cohort study. BMC Infect. Dis. 2021;21:688. doi: 10.1186/s12879-021-06376-1. - DOI - PMC - PubMed

[3] Afzali B, Noris M, Lambrecht BN, Kemper C. The state of complement in COVID-19. Nat. Rev. Immunol. 2022;22:77–84. doi: 10.1038/s41577-021-00665-1. - DOI - PMC - PubMed

[4] Afzali B, Noris M, Lambrecht BN, Kemper C. The state of complement in COVID-19. Nat. Rev. Immunol. 2022;22:77–84. doi: 10.1038/s41577-021-00665-1. - DOI - PMC - PubMed

[5] Ai J, Zhang H, Zhang Y, Lin K, Zhang Y, Wu J, Wan Y, Huang Y, Song J, Fu Z, et al. Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost. Emerg. Microbes Infect. 2022;11:337–343. doi: 10.1080/22221751.2021.2022440. - DOI - PMC - PubMed

[6] Ai J, Zhang H, Zhang Y, Lin K, Zhang Y, Wu J, Wan Y, Huang Y, Song J, Fu Z, et al. Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost. Emerg. Microbes Infect. 2022;11:337–343. doi: 10.1080/22221751.2021.2022440. - DOI - PMC - PubMed

[7] Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, Brassard N, Laumaea A, Gong SY, Bourassa C, et al. Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset. Cell Rep. Med. 2021;2:100290. doi: 10.1016/j.xcrm.2021.100290. - DOI - PMC - PubMed

[8] Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, Brassard N, Laumaea A, Gong SY, Bourassa C, et al. Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset. Cell Rep. Med. 2021;2:100290. doi: 10.1016/j.xcrm.2021.100290. - DOI - PMC - PubMed

[9] Ankerhold J, Giese S, Kolb P, Maul-Pavicic A, Göppert N, Ciminski K, Kreutz C, Lother A, Salzer U, Bildl W, et al. Circulating immune complexes drive immunopathology in COVID-19. 2021. - PMC - PubMed

[10] Ankerhold J, Giese S, Kolb P, Maul-Pavicic A, Göppert N, Ciminski K, Kreutz C, Lother A, Salzer U, Bildl W, et al. Circulating immune complexes drive immunopathology in COVID-19. 2021. - PMC - PubMed

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Protective and pathogenic role of humoral responses in COVID-19

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Protective and pathogenic role of humoral responses in COVID-19

Authors

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Erratum in

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