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Review
. 2022 Jul;42(4):1492-1517.
doi: 10.1002/med.21882. Epub 2022 Mar 2.

Genetically modified cancer vaccines: Current status and future prospects

Xiaoyi Hu  1   2 , Weilin Zhou  2 , Ruyu Pi  1   2 , Xia Zhao  1   2 , Wei Wang  2
Affiliations
Review

Genetically modified cancer vaccines: Current status and future prospects

Xiaoyi Hu et al. Med Res Rev. 2022 Jul.

Abstract

Vaccines can stimulate the immune system to protect individuals from infectious diseases. Moreover, vaccines have also been applied to the prevention and treatment of cancers. Due to advances in genetic engineering technology, cancer vaccines could be genetically modified to increase antitumor efficacy. Various genes could be inserted into cells to boost the immune response, such as cytokines, T cell costimulatory molecules, tumor-associated antigens, and tumor-specific antigens. Genetically modified cancer vaccines utilize innate and adaptive immune responses to induce durable antineoplastic capacity and prevent the recurrence. This review will discuss the major approaches used to develop genetically modified cancer vaccines and explore recent advances to increase the understanding of engineered cancer vaccines.

Keywords: cancer vaccine; gene modification; immune response; tumor.

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References

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