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Comment
. 2022 Mar 1;34(3):350-352.
doi: 10.1016/j.cmet.2022.02.004.

Modulation of cancer immunotherapy by dietary fibers and over-the-counter probiotics

Laurence Zitvogel  1 , Lisa Derosa  2 , Guido Kroemer  3
Affiliations
Free article
Comment

Modulation of cancer immunotherapy by dietary fibers and over-the-counter probiotics

Laurence Zitvogel et al. Cell Metab. .
Free article

Abstract

The human gut microbiota has a major impact on cancer immunosurveillance. In a recent Science paper, Spencer et al. reported the interesting observation that low dietary fiber intake or ingestion of commercially available probiotics both affect the anticancer effects mediated by immunotherapy in mice and patients with advanced melanoma.

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Conflict of interest statement

Declaration of interests L.Z. and G.K. received funding by several food- or microbiota-centered companies (Carrefour, Elior, Kaleido, 9 m) and are scientific co-founders of everImmune, a biotech company developing OncoBax for the treatment of cancer. L.D. was supported by Fondation Philanthropia Gustave Roussy.

Comment on

  • Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.
    Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG, Peterson CB, Wong MC, Morad G, Rodgers T, Badger JH, Helmink BA, Andrews MC, Rodrigues RR, Morgun A, Kim YS, Roszik J, Hoffman KL, Zheng J, Zhou Y, Medik YB, Kahn LM, Johnson S, Hudgens CW, Wani K, Gaudreau PO, Harris AL, Jamal MA, Baruch EN, Perez-Guijarro E, Day CP, Merlino G, Pazdrak B, Lochmann BS, Szczepaniak-Sloane RA, Arora R, Anderson J, Zobniw CM, Posada E, Sirmans E, Simon J, Haydu LE, Burton EM, Wang L, Dang M, Clise-Dwyer K, Schneider S, Chapman T, Anang NAS, Duncan S, Toker J, Malke JC, Glitza IC, Amaria RN, Tawbi HA, Diab A, Wong MK, Patel SP, Woodman SE, Davies MA, Ross MI, Gershenwald JE, Lee JE, Hwu P, Jensen V, Samuels Y, Straussman R, Ajami NJ, Nelson KC, Nezi L, Petrosino JF, Futreal PA, Lazar AJ, Hu J, Jenq RR, Tetzlaff MT, Yan Y, Garrett WS, Huttenhower C, Sharma P, Watowich SS, Allison JP, Cohen L, Trinchieri G, Daniel CR, Wargo JA. Spencer CN, et al. Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015. Epub 2021 Dec 23. Science. 2021. PMID: 34941392 Free PMC article.

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