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Review
. 2022 May;21(5):379-399.
doi: 10.1038/s41573-022-00410-w. Epub 2022 Mar 2.

Therapeutically harnessing extracellular vesicles

Lesley Cheng  1 , Andrew F Hill  2   3
Affiliations
Review

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al. Nat Rev Drug Discov. 2022 May.

Abstract

The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance. The potential of harnessing EVs in the diagnosis and treatment of diseases - including cancer and neurological and cardiovascular disorders - is now being recognized. Accordingly, the applications of EVs as therapeutic targets, biomarkers, novel drug delivery agents and standalone therapeutics are being actively explored. This Review provides a brief overview of the characteristics and physiological functions of the various classes of EV, focusing on their association with disease and emerging strategies for their therapeutic exploitation.

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References

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