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Review
. 2022 Feb 14:16:827284.
doi: 10.3389/fnins.2022.827284. eCollection 2022.

Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders

Yuki Bando  1 , Masaru Ishibashi  2 , Satoru Yamagishi  1 , Atsuo Fukuda  2 , Kohji Sato  1
Affiliations
Review

Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders

Yuki Bando et al. Front Neurosci. .

Abstract

Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this review, we summarize the functions of ion channels and transporters in neocortical development. Next, we discuss links between neurological disorders caused by dysfunction of ion channels (channelopathies) and neocortical development. Finally, we introduce emerging optical techniques with potential applications in physiological studies of neocortical development and the pathophysiology of channelopathies.

Keywords: axon; cerebral cortex; channelopathy; dendrite; ion channel; neurogenesis; neuronal migration; transporter.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Correlation between electrical activity and neocortical development. (i) Proliferation, (ii) neuronal differentiation, (iii) multipolar migration (iv) multipolar-to-bipolar transition, (v) radial migration, (vi) termination of migration, (vii) dendrite and axonal elongation, (viii) synapse formation. VZ, ventricular zone, SVZ, subventricular zone, IZ, intermediate zone, SP, subplate, CP, cortical plate, MZ, marginal zone. The bottom panel shows temporal changes of electrical activity. Electrical activity is high during neurogenesis, low during migration except in the boundary between the IZ and SP, and is elevated again after neurons reach the MZ.
See this image and copyright information in PMC

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