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. 2022;13(2):130-134.
doi: 10.5847/wjem.j.1920-8642.2022.030.

Dynamic observation of bone marrow suppression and chromosomal aberrations in patients with acute colchicine poisoning

Yan-Qing Liu  1 , Xiao-Xia Lu  1   2 , Kai-Xun Hu  1 , Xiao-Bo Peng  1 , Yun Jiang  1 , Li-Mei Han  1 , Zhi-Qiang Ma  1 , Ming-Fei Peng  1 , Kun Wan  1 , Xi-Gang Zhang  1 , Ze-Wu Qiu  1
Affiliations

Dynamic observation of bone marrow suppression and chromosomal aberrations in patients with acute colchicine poisoning

Yan-Qing Liu et al. World J Emerg Med. 2022.
No abstract available

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Conflict of interest statement

Conflicts of interests: All authors declared no conflicts of interests.

Figures

Figure 1
Figure 1
Results of chromosomal abnormalities. A and B: dosage 2.00 mg/kg; A: 65 h after taking the poison, there were two single gaps, three monomer fractures and one acentric centromere (red arrow); B:117 h after taking the poison; C and D: dosage 0.59 mg/kg; C: 114 h after taking the poison. D: 229 h after taking the poison, one monomer fracture (red arrow).
Figure 2
Figure 2
The changes of peripheral blood cells. A: case 1 at 10 d; B: case 1 at 10 d; C: case 2 at 4.75 d; D: case 3 at 2.5 d; E: case 3 at 5 d; F: case 4 at 3.25 d; G: case 5 at 2.75 d; H: case 5 at 5.25 d; I: case 6 at 8 d; J: case 7 at 4 d; K: case 7 at 15 d (time after taking poison). A/E: vacuoles; C: with rod-shaped, globular and teardrop-shaped processes; D: metamyelocyte; F: annular nucleus; G/H/I/J/K: archeocyte (red arrow showed). Case 1/3/7: archeocyte; Case 2/5: poor nuclear lobulation, mature cytoplasm and vacuoles; Case 4/6: granulocytes were binucleate, annular nucleus and annular rod nucleus, with rod-shaped, globular and teardrop-shaped processes.
See this image and copyright information in PMC

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