Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 21:2022:1515274.
doi: 10.1155/2022/1515274. eCollection 2022.

Exhaled Breath Temperature Home Monitoring to Detect NSCLC Relapse: Results from a Pilot Study

Giovanna Elisiana Carpagnano  1 , Todor A Popov  2 , Giulia Scioscia  3   4 , Nicoletta Pia Ardò  4   5 , Donato Lacedonia  3   4 , Mario Malerba  6 , Pasquale Tondo  3 , Piera Soccio  3   4 , Domenico Loizzi  4   5 , Maria Pia Foschino Barbaro  3   4 , Francesco Sollitto  4   5
Affiliations

Exhaled Breath Temperature Home Monitoring to Detect NSCLC Relapse: Results from a Pilot Study

Giovanna Elisiana Carpagnano et al. Biomed Res Int. .

Abstract

Background: Exhaled breath temperature (EBT) has been shown to reflect airway inflammation as well as increased vascularization, both involved in the pathogenesis of lung cancer. The aim of this study was to look for evidence that continuous EBT monitoring by such a device may help the early detection of relapse of lung cancer in patients with NSCLC who have been subjected to surgery with radical intent. Case Series. We included 11 subjects, who had been subjected to lung resection with radical intent for NSCLC in a prospective observational study. All patients received individual devices for EBT measurement and used them daily for 24 months after surgery. Subjects were also followed up by means of regular standard-of-care clinical and radiologic monitoring for lung cancer at four intervals separated by 6 months (T0, T1, T2, T3, and T4). In 5 patients, relapse of lung cancer was documented by means of lung biopsies. All of them recorded an elevation of their EBT at least one-time interval (T1), corresponding to 6 months, before the relapse was diagnosed at T4. The individual EBT graphs over time differed among these patients, and their mean EBT variability increased by +4% towards the end of 24 months of monitoring. By contrast, patients without a relapse did not document an elevation of their EBT and their variability decreased by -1.4%.

Conclusions: Our pilot study provided evidence that continuous EBT monitoring can help in the early detection of lung cancer relapse.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
“X-halo Home” device.
Figure 2
Figure 2
EBT °C at T0-T1-T2-T3-T4 in all patients enrolled.
See this image and copyright information in PMC

References

    1. Boffetta P. IASLC Thoracic Oncology . Elsevier; 2018. Classic Epidemiology of Lung Cancer; pp. 1–8.e3. - DOI
    1. Postmus P. E., Kerr K. M., Oudkerk M., et al. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Annals of Oncology . 2017;28:p. iv1. doi: 10.1093/annonc/mdx222. - DOI - PubMed
    1. Autonoma P., Trento D. I. Linee guida AIOM (Associazione Italiana di Oncologia Medica) Vol. 9. Elsevier; 2009.
    1. Lou F., Huang J., Sima C. S., Dycoco J., Rusch V., Bach P. B. Patterns of recurrence and second primary lung cancer in early-stage lung cancer survivors followed with routine computed tomography surveillance. Journal of Thoracic and Cardiovascular Surgery . 2013;145(1):75–82. doi: 10.1016/j.jtcvs.2012.09.030. - DOI - PubMed
    1. Demicheli R., Fornili M., Ambrogi F., et al. Recurrence dynamics for non-small-cell lung cancer: effect of surgery on the development of metastases. Journal of Thoracic Oncology . 2012;7(4):723–730. doi: 10.1097/JTO.0b013e31824a9022. - DOI - PubMed