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. 1978 Jul;6(1):69-73.
doi: 10.1111/j.1365-2125.1978.tb01684.x.

Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy

D M Rutherford, A Okoko, P J Tyrer

Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy

D M Rutherford et al. Br J Clin Pharmacol. 1978 Jul.

Abstract

1 Plasma concentrations of diazepam and its metabolite, desmethyldiazepam, have been measured in both in- and out-patient groups treated with diazepam for periods varying between 1 month and 10 years. 2 The diazepam concentration was directly related to the dose of diazepam ingested and inversely related to the age of the patient. 3 A highly significant relationship was obtained between the concentration of desmethyldiazepam and diazepam. 4 The plasma concentrations of both diazepam and its metabolite were independent of sex, duration fo therapy and patient group.

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References

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