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. 2021 Nov 23;224(Supplement_5):S469-S474.
doi: 10.1093/infdis/jiab441.

Typhoid in India: An Age-old Problem With an Existing Solution

Supriya Kumar  1 , Raj Shankar Ghosh  2 , Harish Iyer  2 , Arindam Ray  2 , Kirsten Vannice  1 , Calman MacLennan  1 , Tanya Shewchuk  3 , Duncan Steele  1
Affiliations

Typhoid in India: An Age-old Problem With an Existing Solution

Supriya Kumar et al. J Infect Dis. .

Abstract

Enteric fever continues to impact millions of people who lack adequate access to clean water and sanitation. The typhoid and paratyphoid fever burden in South Asia is broadly acknowledged, but current estimates of incidence, severity, and cost of illness from India are lacking. This supplement addresses this gap in our knowledge, presenting findings from two years of surveillance, conducted at multiple sites between October 2017 and February 2020, in the Surveillance for Enteric Fever in India (SEFI) network. Results provide contemporaneous evidence of high disease burden and cost of illness-the latter borne largely by patients in the absence of universal healthcare coverage in India. Against a backdrop of immediate priorities in the COVID-19 pandemic, these data are a reminder that typhoid, though often forgotten, remains a public health problem in India. Typhoid conjugate vaccines, produced by multiple Indian manufacturers, and recommended for use in high burden settings, ensure that the tools to tackle typhoid are an immediately available solution to this public health problem.

Keywords: India; TCV; cost of illness; typhoid.

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References

    1. Barnett R. Typhoid fever. Lancet 2016; 388:2467. http://www.thelancet.com/article/S014067361632178X/fulltext - PubMed
    1. Coats J. Eberth’s typhoid bacillus. Br Med J 1882; 1:421. - PMC - PubMed
    1. Vanderslott S, Phillips MT, Pitzer VE, Kirchhelle C. Water and filth: reevaluating the first era of sanitary typhoid intervention (1840–1940). Clin Infect Dis 2019; 69(Suppl 5):S377–84. https://academic.oup.com/cid/article/69/Supplement_5/S377/5587098 - PMC - PubMed
    1. Cutler D, Miller G. The role of public health improvements in health advances: the twentieth-century United States. Demography 2005; 42:1–22. https://link.springer.com/article/10.1353/dem.2005.0002 - DOI - PubMed
    1. Stanaway JD, Reiner RC, Blacker BF, et al. . The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis 2019; 19:369–81. https://www.sciencedirect.com/science/article/pii/S1473309918306856 - PMC - PubMed

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