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Comment
. 2022 Apr;600(8):1821-1823.
doi: 10.1113/JP282581. Epub 2022 Mar 20.

Could angiotensin-II induced T-cell senescence exacerbate age-related vascular dysfunction?

Ravinandan Venkatasubramanian  1 , Sophia A Mahoney  1 , Zachary S Clayton  1
Affiliations
Comment

Could angiotensin-II induced T-cell senescence exacerbate age-related vascular dysfunction?

Ravinandan Venkatasubramanian et al. J Physiol. 2022 Apr.
No abstract available

Keywords: T-cells; ageing; angiotensin II; arterial stiffness; cellular senescence; endothelial dysfunction; vascular ageing.

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Figures

Figure 1.
Figure 1.. Mechanisms of Angiotensin II-induced senescent T-cells in cardiovascular disease development.
The findings by Trott et al. (2021) demonstrate that dysfunctional T-cells in old mice are involved in inducing vascular inflammation and associated vascular dysfunction. These age-related changes may be caused by Angiotensin II (Ang II)-induced cellular senescence of T-cells. Age-related increases in Ang II and senescent T-cells may be upstream mechanisms stimulating excess reactive oxygen species (ROS)-induced oxidative stress and chronic inflammation which amplify each other to reduce nitric oxide (NO) bioavailability, ultimately causing vascular dysfunction. Reduction in NO bioavailability is linked to impaired vascular function and increased blood pressure and hypertension risk. Taken together, suppressing potentially senescent T-cells may be a novel therapeutic approach to ameliorate inflammation and oxidative stress to favorably impact vascular function and reduce cardiovascular disease (CVD) risk with aging.
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