Recent advances in the preclinical development of responsive MRI contrast agents capable of detecting hydrogen peroxide

Abstract

In this review, we focus on the preclinical development and study of coordination complexes that act as magnetic resonance imaging (MRI) contrast agent sensors for hydrogen peroxide. Redox-responsive probes have been developed that provide signals that can be detected through traditional T₁-weighted ¹H, ¹⁹F, and Chemical Exchange Saturation Transfer MRI. The sensors can also be classified with respect to whether the change in the signal corresponds to the oxidation of the metal ion or the organic ligand.

Keywords: Lanthanides; Magnetic resonance imaging; Redox; Redox-activated ligands; Sensors; Transition metals.