Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar 3;12(3):e056190.
doi: 10.1136/bmjopen-2021-056190.

Association of frailty and cognitive function disorders in old patients with COVID-19: a protocol of systematic review and meta-analysis

Bo Jiao  1 , Mingyuan Chen  2 , Minmin Fan  3 , Xi Luo  4 , Chan Chen  5 , Jin Liu  4
Affiliations

Association of frailty and cognitive function disorders in old patients with COVID-19: a protocol of systematic review and meta-analysis

Bo Jiao et al. BMJ Open. .

Abstract

Introduction: COVID-19 infections have become an urgent worldwide public health concern. Although it is primarily a respiratory disease, up to two-thirds of hospitalised COVID-19 patients exhibit nervous system damage and an increased risk of frailty. In this study,we aim to investigate the relationship between frailty and cognitive function disorders in patients with COVID-19 with a systematic review and meta-analysis approach.

Methods and analysis: This meta-analysis has been registered by the International Prospective Register of Systematic Reviews. We will search for relevant studies from PubMed, Embase, Chinese Biological Medical Database, China National Knowledge Infrastructure, Wanfang Database, the Cochrane Central Register of Controlled Trials databases, from their inception to 5 July 2021. We will also search reference lists of selected articles for additional studies. Our search strategy will have no language restrictions. We will employ a fixed or random-effects model to calculate OR and 95% CIs for pooled data, and assess heterogeneity using Cochrane's Q and I2 tests. The primary outcome will be the rate of cognitive disorders related to frailty in old patients with COVID-19.

Ethics and dissemination: Ethical approval is not essential since data will be extracted from previously published studies. The results of this meta-analysis will be published in a peer-reviewed journal.

Prospero registration number: CRD42021257148.

Keywords: COVID-19; delirium & cognitive disorders; geriatric medicine; mental health; old age psychiatry.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
The flow diagram of literature search and selection.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. The Lancet . India under COVID-19 lockdown. Lancet 2020;395:1315. 10.1016/S0140-6736(20)30938-7 - DOI - PMC - PubMed
    1. Lu H. The epidemic situation in India is almost out of control, and the world is working together to help. International Business Daily, 2004.
    1. Alomari SO, Abou-Mrad Z, Bydon A. COVID-19 and the central nervous system. Clin Neurol Neurosurg 2020;198:106116. 10.1016/j.clineuro.2020.106116 - DOI - PMC - PubMed
    1. Asadi-Pooya AA, Simani L. Central nervous system manifestations of COVID-19: a systematic review. J Neurol Sci 2020;413:116832. 10.1016/j.jns.2020.116832 - DOI - PMC - PubMed
    1. Heneka MT, Golenbock D, Latz E, et al. . Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther 2020;12:69. 10.1186/s13195-020-00640-3 - DOI - PMC - PubMed