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. 2022 Feb 22:2022:4657502.
doi: 10.1155/2022/4657502. eCollection 2022.

Diagnostic and Staging Value of Serum Angiotensin-Converting Enzyme in Sarcoidosis

Wenqiao Wang  1 , Yue Ma  2 , Yongming Zhang  1 , Jiangtao Lin  1 , Jie He  1 , Ying Nong  1 , Xiaoyan Zhang  1 , Yuping Jia  1
Affiliations

Diagnostic and Staging Value of Serum Angiotensin-Converting Enzyme in Sarcoidosis

Wenqiao Wang et al. Comput Math Methods Med. .

Retraction in

Abstract

Objective: To investigate the diagnostic and staging value of serum angiotensin-converting enzyme (sACE) in sarcoidosis.

Methods: Patients with suspected sarcoidosis treated in the Department of Pulmonary and Critical Care Medicine of the China-Japan Friendship Hospital from 2010 to 2020 were included. The data of sACE, erythrocyte sedimentation rate (ESR), complete blood count (CBC), lung function, bronchoalveolar lavage, and biopsy were collected. The differences between the sarcoidosis group and the nonsarcoidosis group and between different stages of sarcoidosis were compared. The receiver operating characteristic (ROC) curve analysis was used for the diagnostic test of sACE in sarcoidosis.

Results: A total of 84 cases with suspected sarcoidosis were included, among which 70 cases were confirmed to be sarcoidosis by biopsy. The mean value of sACE in sarcoidosis patients was 56.61 ± 30.80 U/L, which was significantly higher than that in nonsarcoidosis patients (28.07 ± 14.11 U/L, P = 0.001). The level of sACE in sarcoidosis patients with peripheral superficial lymph nodes and multiple system involvement was significantly higher than that in intrathoracic sarcoidosis patients (P = 0.009); the percentage of lymphocytes in bronchoalveolar lavage fluid (BALF) of sarcoidosis patients was 45.39 ± 22.87%, which was significantly higher than that of nonsarcoidosis patients (P < 0.001). There was no correlation between sACE and ESR (correlation coefficient = -0.167). According to ROC curve analysis, when sACE ≥ 44.0 U/L, the sensitivity of sarcoidosis diagnosis was 61.4%, the specificity was 92.9%, and the AUC was 0.819.

Conclusion: sACE has a good specificity in the diagnosis of sarcoidosis. sACE values in patients with sarcoidosis with systemic involvement were higher than those with simple intrathoracic sarcoidosis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
ROC curve of sACE for the diagnosis of sarcoidosis in suspected cases.
Figure 2
Figure 2
Correlation analysis between sACE and ESR.
See this image and copyright information in PMC

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References

    1. Ungprasert P., Carmona E. M., Utz J. P., Ryu J. H., Crowson C. S., Matteson E. L. Epidemiology of sarcoidosis 1946-2013: a population-based study. Mayo Clinic Proceedings . 2016;91(2):183–188. doi: 10.1016/j.mayocp.2015.10.024. - DOI - PMC - PubMed
    1. Baughman R. P., Teirstein A. S., Judson M. A., et al. Clinical characteristics of patients in a case control study of sarcoidosis. American Journal of Respiratory and Critical Care Medicine . 2001;164(10):1885–1889. doi: 10.1164/ajrccm.164.10.2104046. - DOI - PubMed
    1. Rizzato G., Tinelli C. Unusual presentation of sarcoidosis. Respiration . 2005;72(1):3–6. doi: 10.1159/000083392. - DOI - PubMed
    1. Rizzato G., Palmieri G., Agrati A. M., Zanussi C. The organ-specific extrapulmonary presentation of sarcoidosis: a frequent occurrence but a challenge to an early diagnosis. A 3-year-long prospective observational study. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases . 2004;21:119–126. - PubMed
    1. Yoon H. Y., Kim H. M., Kim Y. J., Song J. W. Prevalence and incidence of sarcoidosis in Korea: a nationwide population-based study. Respiratory Research . 2018;19(1):p. 158. doi: 10.1186/s12931-018-0871-3. - DOI - PMC - PubMed

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