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Review
. 2022 Jan 17:16:1344.
doi: 10.3332/ecancer.2022.1344. eCollection 2022.

Dihydropyrimidine dehydrogenase (DPD) polymorphisms knocking on the door

Mauro Daniel Spina Donadio  1 , Dirce Maria Carraro  2   1 , Giovana Tardin Torrezan  2   1 , Celso Abdon Lopes de Mello  2   1
Affiliations
Review

Dihydropyrimidine dehydrogenase (DPD) polymorphisms knocking on the door

Mauro Daniel Spina Donadio et al. Ecancermedicalscience. .

Abstract

Identifying polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) genes is gaining importance as predictors of fluoropyrimidine-associated toxicity. The recommendation of dose adjustment for chemotherapy guided by the presence of polymorphisms of the DPYD gene can potentially improve treatment safety for a large number of patients, saving lives, avoiding complications and reducing health care costs. This article discusses how personalisation of fluoropyrimidine treatment based on the identification of DPYD variants can mitigate toxicities and be cost effective.

Keywords: dihydropyrimidine dehydrogenase; fluoropyrimidine; polymorphisms.

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Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.. Absolute number of patients at risk considering only colorectal cancer in Brazil (patients at risk considering the sum of MAF (ABraOM)).
See this image and copyright information in PMC

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