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. 2022 Jan;11(1):33-40.
doi: 10.21037/tp-21-516.

Efficacy of phentolamine combined with ambroxol aerosol inhalation in the treatment of pediatric severe pneumonia and its effect on serum IL-10 and CRP levels

Junxia Li  1 , Haixia Wu  1 , Jingyao Zhang  2
Affiliations

Efficacy of phentolamine combined with ambroxol aerosol inhalation in the treatment of pediatric severe pneumonia and its effect on serum IL-10 and CRP levels

Junxia Li et al. Transl Pediatr. 2022 Jan.

Abstract

Background: The aim of the present study was to determine the therapeutic effect of phentolamine combined with Ambroxol aerosol inhalation on pediatric severe pneumonia and its effect on serum interleukin-10 (IL-10) and C-reactive protein (CRP) levels.

Methods: Eighty-five children with severe pneumonia treated in our hospital from November 2019 to November 2020 were selected as the research participants, and were divided into the routine group (n=41) and treatment group (n=44) according to odd and even admission numbers, respectively. Children in the first group received routine treatment, namely symptomatic treatment such as cough relief (e.g., expectorant) and defervescence, while those in the second group received phentolamine combined with Ambroxol aerosol inhalation. Clinical indexes of both groups before and after treatment were analyzed to determine the therapeutic effect of different treatment methods and serum IL-10 and CRP level changes.

Results: There was no significant difference in general clinical data between the 2 groups (P>0.05). The duration of cough, fever, abnormal lung sound and lung shadow, and hospitalization time in the treatment group was significantly shorter than those in the routine group (P<0.001). The total clinical effective rate in the treatment group was significantly higher than that in the routine group (P<0.05). Forced vital capacity and peak expiratory flow rate levels were higher in both groups after treatment (P<0.05), and these were higher in the treatment group compared with the routine group after treatment (P<0.05). Serum IL-10 and CRP levels at T1 (2 days after treatment), T2 (5 days after treatment), and T3 (7 days after treatment) in the treatment group were significantly lower than those in the routine group (P<0.001). The total incidence of adverse reactions in the treatment group was significantly lower than that in the routine group (P<0.05).

Conclusions: Phentolamine combined with Ambroxol aerosol inhalation can significantly improve the clinical symptoms of children with severe pneumonia, reduce the body's inflammatory response, and improve lung function safely.

Keywords: C-reactive protein (CRP); Phentolamine; ambroxol aerosol inhalation; pediatric severe pneumonia; serum interleukin-10 (IL-10).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-21-516/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Comparison of forced vital capacity (FVC) levels before and after treatment between the 2 groups. FVC levels in the treatment group before and after treatment were 1.26±0.23 L and 1.91±0.37 L, respectively. FVC levels in the routine group before and after treatment were 1.28±0.25 and 1.64±0.34 L, respectively. *: t=9.644, P=0.000; **: t=5.528, P=0.000; ***: t=3.506, P=0.001.
Figure 2
Figure 2
Comparison of peak expiratory flow rate (PEF) levels before and after treatment between the 2 groups. PEF levels in the treatment group before and after treatment were 1.68±0.43 and 3.44±1.22 L/s, respectively. PEF levels in the routine group before and after treatment were 1.70±0.42 and 2.86±1.03 L/s, respectively. *: t=8.742, P=0.000; **: t=6.708, P=0.000; ***: t=2.374, P=0.020.
Figure 3
Figure 3
Comparison of interleukin-10 (IL-10) levels between the 2 groups at different time points. IL-10 levels in the treatment group at T0 (before treatment), T1 (2 days after treatment), T2 (5 days after treatment), and T3 (7 days after treatment) were 39.43±4.79, 30.62±3.84, 22.15±3.17, and 13.62±2.86 pg/mL, respectively. IL-10 levels in the routine group at T0, T1, T2, and T3 were 39.47±4.71, 34.71±3.76, 28.34±3.24, and 19.77±2.69 pg/mL, respectively. *: t=4.960, P=0.000; **: t=8.894, P=0.000; ***: t=10.216, P=0.000.
Figure 4
Figure 4
Comparison of C-reactive protein (CRP) levels between the 2 groups at different time points. CRP levels in the treatment group at T0 (before treatment), T1 (2 days after treatment), T2 (5 days after treatment), and T3 (7 days after treatment) were 54.32±7.52, 39.63±5.43, 20.07±3.26, and 7.32±1.45 mg/L, respectively. CRP levels in the routine group at T0, T1, T2, and T3 were 54.37±7.49, 44.47±5.28, 27.42±3.19, and 13.69±1.52 mg/L, respectively. *: t=4.166, P=0.000; **: t=10.503, P=0.000; ***: t=19.739, P=0.000.
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