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. 2020 Sep 21:7:2374289520956361.
doi: 10.1177/2374289520956361. eCollection 2020 Jan-Dec.

Educational Case: Myeloid Sarcoma: A Subtype of Acute Myeloid Leukemia

Ananya Datta Mitra  1 , Nam Kyun Ku  2 , Elham Vali Betts  1
Affiliations

Educational Case: Myeloid Sarcoma: A Subtype of Acute Myeloid Leukemia

Ananya Datta Mitra et al. Acad Pathol. .

Abstract

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.

Keywords: Myeloid sarcoma; classification of acute myeloid leukemias; hematopathology; immunohistochemistry; myeloid neoplasia; organ system pathology; pathology competencies; white cell disorder.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
High power (Cellavision software image of peripheral blood smear equivalent to 100×) view of peripheral blood smear showing peripheral blasts. The cells are large in size with open chromatin, irregular nuclear membrane, high Nuclear-Cytoplasmic ratio, and occasional prominent nucleoli.
Figure 2.
Figure 2.
Low power (2×) view of hematoxylin and eosin (H&E) stained slide showing an expanded epidermis (acanthosis) overlying an expanded dermis infiltrated diffusely by an atypical cellular infiltrate. The cells in the infiltrate are immature cells involving the papillary and reticular dermis.
Figure 3.
Figure 3.
A high-power view (40×) of the tumor cells from the skin lesion. The cells are immature with scant cytoplasm, high nuclear to cytoplasmic ratio, round to oval nuclei with finely dispersed chromatin, and prominent nucleoli. There are occasional small mature lymphocytes in the background. Increased number of mitotic figures are noted. There is no necrosis and acute inflammation.
Figure 4.
Figure 4.
Oil emersion field (100×) view of numerous immature cells (see black arrows). The cells are large in size, have high nuclear to cytoplasmic ratio, round to oval nuclei with irregular nuclear membrane, finely dispersed chromatin, and prominent nucleoli.
Figure 5.
Figure 5.
High-power view (40×) of the neoplastic cells showing strong positivity for CD43, myeloperoxidase (MPO), and CD68 and are negative for CD4.
See this image and copyright information in PMC

References

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