Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Feb 14:5:401-413.
doi: 10.1016/j.crfs.2022.02.005. eCollection 2022.

Extraction and determination of flubendiamide insecticide in food samples: A review

S Aghris  1 , O Tahiri Alaoui  2 , F Laghrib  1   3 , A Farahi  1 , M Bakasse  1   4 , S Saqrane  1 , S Lahrich  1 , M A El Mhammedi  1
Affiliations
Review

Extraction and determination of flubendiamide insecticide in food samples: A review

S Aghris et al. Curr Res Food Sci. .

Abstract

Flubendiamide (FBD) is the first commercially available phthalic acid diamide that targets ryanodine receptors (RyRs) in insects, which play a major role in lepidoptera control. However, excessive use of FBD can influence the quality of treated products leading to toxic effects on human health. The availability of rapid and convenient methods for evaluating FBD amount in the environment is necessary. Therefore, analytical methods were developed for the determination of residues of FBD and its metabolite desiodo in different food matrices like tomato, cabbage, pigeon pea, apple, chilli and rice. The current review carries forward methods for FBD residues analysis in foods by using several chromatographic techniques including sample preparation steps. The comparison between the different methods employed for quantitative and qualitative analysis of food quality and safety is also discussed. Liquid chromatography (LC) is the predominant analytical method for assessing the quality of foods treated with FBD. Studies related to LC coupled multichannel detector (Ultraviolet (UV), Mass spectrometry (MS)) are also applied to detect pesticide residues. Extraction and clean up steps are essential to obtain reliable results. Moreover, this review reports the allowed limits of residues for the safety of consuming products treated with FBD.

Keywords: Chromatographic analysis; Flubendiamide; Food samples; Lepidoptera pest; RyRs.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Chemical structure of clorantraniliprole and cyantraniliprole.
Fig. 2
Fig. 2
Chemical structure of (A) phthalic diamide and (B) flubendiamide.
Fig. 3
Fig. 3
Schematic illustration of the synthesis of flubendiamide.
Fig. 4
Fig. 4
Mode of action of flubendiamide on lepidoptera pest.
Fig. 5
Fig. 5
Analytical procedure for determining pesticide in food matrices.
See this image and copyright information in PMC

References

    1. Abbas M.S., Soliman A.S., El-Gammal H.A., Amer M.E., Attallah E.R. Development and validation of a multiresidue method for the determination of 323 pesticide residues in dry herbs using QuEChERS method and LC-ESI-MS/MS. Int. J. Environ. Anal. Chem. 2017;97:1003–1023.
    1. Aghris S., Ajermoun N., Hrioua A., Laghrib F., El Bouabi S., Saqrane S., Farahi A., Bakasse M., Lahrich S., El Mhammedi M.A. Electrochemical determination of flubendiamide insecticide at graphite/ionic liquid/natural phosphate: application in water and white rice. Cas. Stud. Chem. Envi. Eng. 2022;10179:1–7.
    1. Aghris S., Ajermoun N., Loudiki A., Ettadili F.E., Laghrib F., Farahi A., El Mhammedi M.A. Disposal graphite pencil sensor for trace detection of phthalic acid diamide insecticide flubendiamide in wastewater and white rice. Int. J. Environ. Anal. Chem. 2021:1–13.
    1. Aghris S., Matrouf M., Ettadili F.E., Laghrib F., El Bouabi Y., Saqrane S., El Mhammedi M.A. Electrochemical analysis of flubendiamide in water and white rice using clay microparticles supported on pencil electrode. Microw. J. 2021;168
    1. Ahlawat S., Gulia S., Malik K., Rani S., Chauhan R. Persistence and decontamination studies of chlorantraniliprole in Capsicum annum using GC–MS/MS. J. Food Sci. Technol. 2019;56:2925–2931. - PMC - PubMed

LinkOut - more resources