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. 2022 May;57(5):1363-1365.
doi: 10.1002/ppul.25881. Epub 2022 Mar 11.

Fatal SARS-CoV-2 Omicron variant in a young infant: Autopsy findings

Pierre Goussard  1 , Pawel Schubert  2   3 , Noor Parker  1 , Chantelle Myburgh  1 , Helena Rabie  1 , Marieke M van der Zalm  1 , Gert U Van Zyl  3   4 , Wolfgang Preiser  3   4 , Tongai G Maponga  3   4 , Janette Verster  5 , Andre G Gie  1 , Savvas Andronikou  6   7
Affiliations

Fatal SARS-CoV-2 Omicron variant in a young infant: Autopsy findings

Pierre Goussard et al. Pediatr Pulmonol. 2022 May.
No abstract available

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Figures

Figure 1
Figure 1
(A) Day 1: Bilateral, symmetric “ground‐glass” density throughout both lungs. (B) Day 6: Tension pneumothorax on the left and a basal pneumothorax on the right. (C) Day 8: Bilateral thoracic pig‐tail drains and additional basal thoracic drain with the tip overlying the cardiac shadow. PIE in the medial portion of the left lung and lower medial portions of the right lung. (D) Day 12: Re‐accumulation of bilateral pneumothoraces and progression of PIE in both lungs. (E) Day 14: Reposition of left‐sided pigtail drain and new left basal chest drain with improvement of the left pneumothorax, but further expansion of right pneumothorax and worsening of bilateral PIE. PIE, pulmonary interstitial emphysema
Figure 2
Figure 2
(A) Right lung showing a rather solid appearance with widespread organizing pneumonia. Hematoxylin and Eosin stain, 4×. (B) Higher magnification of organizing pneumonia with fibrin ball‐like collections in the alveolar spaces that are already showing signs of organization. The interstitium is expanded with chronic inflammatory cell infiltrates. Hematoxylin and Eosin stain, 10×. (C) High power magnification of the lung, showing a very solid, diffusely fibrotic lung (fibrosing organizing pneumonia) with a few visible alveoli that contain multinucleated giant cells in the alveolar spaces. Hematoxylin and Eosin stain, 20×. (D) Low power magnification of the lung section showing some alveoli with organizing pneumonia while others still contain hyaline membranes lining the alveolar walls with the alveolar lumens still being patent and containing some inflammatory cells. The interstitium is expanded with acute and chronic inflammatory cells. Hematoxylin and Eosin stain, 10×. (E) Low magnification photograph showing the pleural space top left with a hemorrhagic, wedge‐shaped pleural infarct. Hematoxylin and Eosin stain, 4×. (F) High magnification of (E), highlighting the infarcted nature of the lung parenchyma. Hematoxylin and Eosin stain, 10×. (G) Photograph of a pulmonary artery contains a large, but nonocclusive thrombus. Hematoxylin and Eosin stain, 10×. (H) Low magnification image of subpleural lung parenchyma (pleural space top left corner) showing dilated lymphatic channels (the lining of which are D2‐40 positive on immunohistochemical staining), giving a “microcystic” appearance to this section of the lung parenchyma, compressing the adjacent lung lobules. Hematoxylin and Eosin stain, 4×. (I) Low magnification image with the pleural space being seen top right. The pulmonary artery and vein are seen “hanging” in clear spaces which are dilated lymphatic channels. Hematoxylin and Eosin stain, 4×. (J) Section of the right ventricle with a thrombus seen attached to the wall of the ventricle and propagating into the ventricular lumen. Hematoxylin and Eosin stain, 10× [Color figure can be viewed at wileyonlinelibrary.com]
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References

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Supplementary concepts