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. 2022 Jan-Dec:21:23259582221084543.
doi: 10.1177/23259582221084543.

Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania

Mary Spicar Kilapilo  1 , Raphael Zozimus Sangeda  1 , George M Bwire  1 , Godfrey Leonard Sambayi  2 , Idda Hubert Mosha  3 , Japhet Killewo  4
Affiliations

Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania

Mary Spicar Kilapilo et al. J Int Assoc Provid AIDS Care. 2022 Jan-Dec.

Abstract

Background: Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania. Methods: A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020. Results: A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval]: 2.38 - 7.91, p-value < 0.0001). Conclusions: Sustainable adherence counseling is warranted to overcome non-adherence to ART.

Keywords: Dar es Salaam; HIV; Tanzania; adherence; antiretroviral therapy; dolutegravir; people living with HIV.

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Conflict of interest statement

Authors’ Contributions: MK and RZS participated in conceptualization, design, data collection, analysis, and manuscript drafting. IHM & GS participated in study design and analysis. GB participated in data analysis and manuscript revisions. RS participated in conceptualization, study design, data analysis and manuscript revision. All authors have read and approved the final version of the manuscript.

Consent to Publish: Not applicable.

Availability of Data and Materials: Data sets used to draw a conclusion of this study are available from the corresponding author on reasonable request.

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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