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Review
. 2022 May;65(5):751-762.
doi: 10.1007/s00125-022-05666-w. Epub 2022 Mar 4.

When therapeutic drugs lead to diabetes

Bruno Fève  1   2 , André J Scheen  3   4
Affiliations
Review

When therapeutic drugs lead to diabetes

Bruno Fève et al. Diabetologia. 2022 May.

Abstract

Drug-induced diabetes mellitus is a growing problem in clinical practice. New, potent medications contribute to this problem in a population already at high risk of developing glucose disturbances because of poor lifestyle habits and high prevalence of being overweight/obese. The present review focuses on four important pharmacological classes: glucocorticoids; antipsychotics, especially second generation; antiretroviral therapies, which revolutionised the management of individuals with HIV; and immune checkpoint inhibitors, recently used for the immunotherapy of cancer. For each class, the prevalence of drug-induced diabetes will be evaluated, the most common clinical presentations will be described, the underlying mechanisms leading to hyperglycaemia will be briefly analysed, and some recommendations for appropriate monitoring and management will be proposed.

Keywords: Antipsychotics; Antiretroviral therapy; Drug-induced diabetes; Glucocorticoids; Immune checkpoint inhibitors; Review; Secondary diabetes.

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Comment in

  • Nebenwirkung Diabetes.
    Kraus D. Kraus D. MMW Fortschr Med. 2022 Apr;164(8):12-14. doi: 10.1007/s15006-022-1069-7. MMW Fortschr Med. 2022. PMID: 35449255 German. No abstract available.

References

    1. Fathallah N, Slim R, Larif S, Hmouda H, Ben Salem C (2015) Drug-induced hyperglycaemia and diabetes. Drug Saf 38(12):1153–1168. https://doi.org/10.1007/s40264-015-0339-z - DOI - PubMed
    1. Liu MZ, He HY, Luo JQ et al (2018) Drug-induced hyperglycaemia and diabetes: pharmacogenomics perspectives. Arch Pharm Res 41(7):725–736. https://doi.org/10.1007/s12272-018-1039-x - DOI - PubMed
    1. Guber K, Pemmasani G, Malik A, Aronow WS, Yandrapalli S, Frishman WH (2021) Statins and higher diabetes mellitus risk: incidence, proposed mechanisms and clinical implications. Cardiol Rev 29(6):314–322. https://doi.org/10.1097/CRD.0000000000000348 - DOI - PubMed
    1. Suh S, Park MK (2017) Glucocorticoid-induced diabetes mellitus: an important but overlooked problem. Endocrinol Metab (Seoul) 32(2):180–189. https://doi.org/10.3803/EnM.2017.32.2.180 - DOI
    1. Reynolds RM, Labad J, Sears AV et al (2012) Glucocorticoid treatment and impaired mood, memory, and metabolism in people with diabetes: the Edinburgh type 2 diabetes study. Eur J Endocrinol 166(5):861–868. https://doi.org/10.1530/EJE-12-004 - DOI - PubMed - PMC

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