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. 2022 Oct;15(5):1086-1099.
doi: 10.1007/s12265-022-10227-y. Epub 2022 Mar 4.

Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells

Ning Yang  1 , Bo Dong  1 , Yanqiu Song  1 , Yang Li  1 , Lu Kou  1 , Qin Qin  2
Affiliations

Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells

Ning Yang et al. J Cardiovasc Transl Res. 2022 Oct.

Abstract

This research investigated the mechanism of CLU in vascular restenosis by regulating vascular smooth muscle cell (VSMC) proliferation and migration. Firstly, rat models of balloon injury (BI) were established, followed by the assessment of the injury to the common carotid artery. The effect of CLU on the intimal hyperplasia of BI rats was measured after the intervention in CLU, in addition to the evaluation of proliferation, migration, and autophagy of VSMCs. Moreover, the interaction between ATG and LC3 was analyzed, followed by validation of the role of autophagy in CLU's regulation on the proliferation and migration of VSMCs. It was found that CLU was highly expressed in BI rats. Altogether, our findings indicated that CLU was highly expressed in vascular restenosis, and CLU over-expression promoted the binding between ATG3 and LC3, thus facilitating VSMC autophagy and eventually attenuating intimal hyperplasia and vascular restenosis.

Keywords: Apolipoprotein J; Migration; Proliferation; Vascular restenosis; Vascular smooth muscle cells.

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References

    1. Anderson, L., Thompson, D. R., Oldridge, N., et al. (2016). Exercise-based cardiac rehabilitation for coronary heart disease. The Cochrane Database of Systematic Reviews, 2016(1):CD001800. https://doi.org/10.1002/14651858.CD001800.pub3
    1. Jeong, Y. J., Ahn, J. M., Hyun, J., et al. (2021). Ten-year Outcomes After Drug-Eluting Stents or Bypass Surgery for Left Main Coronary Disease in Patients With and Without Diabetes Mellitus: The PRECOMBAT Extended Follow-Up Study. Journal of the American Heart Assocation, 10, e019834. - DOI
    1. Fu, C., Wang, H., Wei, Q., et al. (2019). Effects of rehabilitation exercise on coronary artery after percutaneous coronary intervention in patients with coronary heart disease: A systematic review and meta-analysis. Disability and Rehabilitation, 41, 2881–2887. - DOI - PubMed
    1. Zhu, B., Gong, Y., Shen, L., et al. (2020). Total Panax notoginseng saponin inhibits vascular smooth muscle cell proliferation and migration and intimal hyperplasia by regulating WTAP/p16 signals via m(6)A modulation. Biomedicine and Pharmacotherapy, 124, 109935. - DOI - PubMed
    1. Liu, J., Liu, Z., Hu, X., et al. (2018). Synthetic E-selectin prevents postoperative vascular restenosis by inhibiting nuclear factor kappaB in rats. Molecular Medicine Reports, 17, 5065–5073. - PubMed - PMC

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