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Comment
. 2022 Mar 4;7(69):eabo6765.
doi: 10.1126/sciimmunol.abo6765. Epub 2022 Mar 4.

MTHFD2, metabolic mastermind of CD4+ T cell destiny

Victoire Gouirand  1 , Michael D Rosenblum  1
Affiliations
Comment

MTHFD2, metabolic mastermind of CD4+ T cell destiny

Victoire Gouirand et al. Sci Immunol. .

Abstract

MTHFD2 is a metabolic checkpoint of T cell fate and function.

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  • MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
    Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. Sugiura A, et al. Immunity. 2022 Jan 11;55(1):65-81.e9. doi: 10.1016/j.immuni.2021.10.011. Epub 2021 Nov 11. Immunity. 2022. PMID: 34767747 Free PMC article.

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