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Editorial
. 2022 Mar;18(3):389-392.
doi: 10.1002/alz.12633. Epub 2022 Mar 4.

"Exceptions that prove the rule"-Why have clinical trials failed to show efficacy of risk factor interventions suggested by observational studies of the dementia-Alzheimer's disease syndrome?

John C S Breitner  1 , Hiroko H Dodge  2 , Zaven S Khachaturian  3 , Ara S Khachaturian  3
Affiliations
Editorial

"Exceptions that prove the rule"-Why have clinical trials failed to show efficacy of risk factor interventions suggested by observational studies of the dementia-Alzheimer's disease syndrome?

John C S Breitner et al. Alzheimers Dement. 2022 Mar.
No abstract available

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Figures

Figure 1.
Figure 1.
Proposed triaxial classification of factors that may modify outcomes in the dementia–AD syndrome
See this image and copyright information in PMC

References

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    1. Peters R, Dodge HH, James S, et al. The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven’t lived up to expectations, and where do we go from here? Alzheimers Dement. 2021. - PubMed
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    1. Rabinovici GD, Carrillo MC, Forman M, et al. Multiple comorbid neuropathologies in the setting of Alzheimer’s disease neuropathology and implications for drug development. Alzheimer’s & dementia : translational research & clinical interventions. 2017;3(1):83–91. - PMC - PubMed

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