Where the heart beats
- PMID: 35245434
- DOI: 10.1016/j.str.2022.02.006
Where the heart beats
Abstract
In this issue of Structure, Reddy et al. present details about the structure, topology, and dynamics of the small membrane protein DWORF, a regulin that activates the Ca2+ pump SERCA. State-of-the art oriented solid-state NMR spectroscopy in combination with molecular dynamics simulations reveal the structure of this cardiac muscle protein.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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A kink in DWORF helical structure controls the activation of the sarcoplasmic reticulum Ca2+-ATPase.Structure. 2022 Mar 3;30(3):360-370.e6. doi: 10.1016/j.str.2021.11.003. Epub 2021 Dec 6. Structure. 2022. PMID: 34875216 Free PMC article.
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